Unlocking the Potential of Oxymatrine: A Comprehensive Review of Its Neuroprotective Mechanisms and Therapeutic Prospects in Neurological Disorders.

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

ACS Chemical Neuroscience Pub Date : 2024-11-14 DOI:10.1021/acschemneuro.4c00338

Yogita Dhurandhar, Shubham Tomar, Ashmita Das, As Pee Singh, Jeevan Lal Prajapati, Surendra H Bodakhe, Kamta P Namdeo

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Abstract

Sophora flavescens, the source of oxymatrine, is gaining popularity due to its potential in neuroprotection and treatment of various neurological conditions like epilepsy, depression, Parkinson's, Alzheimer's and multiple sclerosis. Its natural occurrence and promising preliminary research highlight its ability to reduce nerve cell damage and inflammation, attributed to its antiapoptotic, antioxidant and anti-inflammatory properties. However, challenges like solubility, potential adverse effects and limited bioavailability hinder its full therapeutic utilization. Current strategies, including formulation optimization and innovative drug delivery systems, aim to enhance its efficacy and safety. Despite its potential, further research is necessary to overcome these obstacles and maximize its clinical effectiveness. Conclusively, oxymatrine demonstrates distinct neuroprotective properties, offering unique advantages over other agents currently being studied or used in clinical practice for neurological disorders. nevertheless, additional study is necessary to surmount current obstacles and maximize its effectiveness for clinical settings. This study provides a comprehensive overview of oxymatrine's neuroprotective mechanisms and therapeutic potential while emphasizing the need for continued investigation and development for practical clinical application.

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释放氧化苦参碱的潜力：全面评述氧化苦参碱的神经保护机制及其在神经系统疾病中的治疗前景。

槐花是氧化苦参碱的来源，由于其在神经保护和治疗各种神经疾病（如癫痫、抑郁症、帕金森氏症、阿尔茨海默氏症和多发性硬化症）方面的潜力，它正日益受到人们的青睐。由于其具有抗凋亡、抗氧化和抗炎特性，它的天然存在和前景广阔的初步研究凸显了其减少神经细胞损伤和炎症的能力。然而，溶解性、潜在的不良反应和有限的生物利用度等挑战阻碍了它的全面治疗利用。目前的策略包括优化配方和创新给药系统，旨在提高其疗效和安全性。尽管土贝母具有很大的潜力，但要克服这些障碍并最大限度地提高其临床疗效，还需要进一步的研究。最终，氧化苦参碱显示出独特的神经保护特性，与目前正在研究或临床用于治疗神经系统疾病的其他药物相比，具有独特的优势。本研究全面概述了氧化苦参碱的神经保护机制和治疗潜力，同时强调了继续研究和开发其临床实际应用的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Chemical Neuroscience BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICINAL

CiteScore

9.20

自引率

4.00%

发文量

323

审稿时长

1 months

期刊介绍： ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry such as the following: Neurotransmitters and receptors Neuropharmaceuticals and therapeutics Neural development—Plasticity, and degeneration Chemical, physical, and computational methods in neuroscience Neuronal diseases—basis, detection, and treatment Mechanism of aging, learning, memory and behavior Pain and sensory processing Neurotoxins Neuroscience-inspired bioengineering Development of methods in chemical neurobiology Neuroimaging agents and technologies Animal models for central nervous system diseases Behavioral research