Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2024-11-14 DOI:10.1186/s12943-024-02171-z

Chang Zhu, Jing-Yu Liao, Yi-Yang Liu, Ze-Yu Chen, Rui-Zhi Chang, Xiao-Ping Chen, Bi-Xiang Zhang, Jun-Nan Liang

引用次数: 0

Abstract

Liver metastases are commonly detected in the advanced stages of various malignant tumors, representing a significant clinical challenge. Throughout the process of liver metastases formation, immune cells play a pivotal role, particularly in the pre-metastatic and metastatic niches within the liver. Immune cells establish extensive and intricate interactions with tumor cells and other components in the liver, collectively promoting and sustaining the growth of liver metastases. Despite the limited efficacy of existing therapeutic modalities against some advanced liver metastases, novel immune-based treatment approaches are continuously being explored and validated. Building on the systematic elucidation of the immunosuppressive characteristics of liver metastases, we explored the potential of novel immunotherapies applicable to patients with liver metastases from multiple dimensions.

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形成肝转移瘤转移前和转移壁龛的免疫动态：从分子机制到治疗策略

肝转移通常在各种恶性肿瘤的晚期阶段被发现，是一项重大的临床挑战。在肝转移瘤形成的整个过程中，免疫细胞发挥着举足轻重的作用，尤其是在肝脏内的转移前和转移龛中。免疫细胞与肿瘤细胞和肝脏中的其他成分建立广泛而复杂的相互作用，共同促进和维持肝转移灶的生长。尽管现有治疗方法对某些晚期肝转移瘤的疗效有限，但人们仍在不断探索和验证基于免疫的新型治疗方法。在系统阐明肝转移瘤免疫抑制特征的基础上，我们从多个维度探索了适用于肝转移瘤患者的新型免疫疗法的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

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