Itaconate promotes an unexpected tumor immune escape mechanism

IF 48.8 1区 医学 Q1 CELL BIOLOGY
Lara Haase, Christian Frezza
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引用次数: 0

Abstract

Itaconate is a metabolite produced by macrophages upon infection and acts as an antimicrobial molecule. In this issue of Cancer Cell, Lin et al. found that itaconate produced by tumor-associated macrophages is taken up by cancer cells via the transporter solute carrier family 13 member 3 (SLC13A3), promoting resistance to immune checkpoint inhibitors.
伊塔康酸促进一种意想不到的肿瘤免疫逃逸机制
伊他康酸是巨噬细胞在感染时产生的一种代谢产物,是一种抗菌分子。在本期《癌细胞》(Cancer Cell)杂志上,Lin 等人发现,肿瘤相关巨噬细胞产生的伊他康酸可通过转运体溶质运载家族 13 成员 3(SLC13A3)被癌细胞吸收,从而促进癌细胞对免疫检查点抑制剂产生抗药性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancer Cell
Cancer Cell 医学-肿瘤学
CiteScore
55.20
自引率
1.20%
发文量
179
审稿时长
4-8 weeks
期刊介绍: Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.
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