Effect of infusion line connection and infusion line characteristics on start-up fluid delivery from syringe infusion pumps used for microinfusion.

IF 1.7 4区医学 Q2 ANESTHESIOLOGY

Pediatric Anesthesia Pub Date : 2024-11-07 DOI:10.1111/pan.15031

Markus Weiss, Pedro David Wendel-Garcia, Vincenzo Cannizzaro, Maren Kleine-Brueggeney

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引用次数: 0

Abstract

Background: Connecting an infusion line to a closed stopcock results in pressurization of fluid within the syringe infusion pump assembly leading to flow irregularities when opening the stopcock and activating the pump.

Aims: It was the purpose of this study to assess the extent of pressurization under different conditions and its impact on start-up fluid delivery.

Methods: Intraluminal pressures and start-up fluid delivery at 1 mL/h flow rate were assessed with connection of the infusion line 1 min (delayed connection) or immediately after purging (immediate connection) using two different infusion lines made from polyvinylchloride (PVC) or polyethylene (PE).

Results: Delayed connection resulted in an increase of intraluminal pressures from zero to 5.1 [4.5 to 5.7] mmHg with the PVC line and from zero to 47.1 [44.8 to 49.3] mmHg with the PE line (mean difference 42.0 [95% CI 39.3-44.7] mmHg; p < .0001). Immediate connection resulted in an increase of intraluminal pressures from zero to 44.3 [41.8-46.8] mmHg with the PVC line and from zero to 61.3 [57.2-65.4] mmHg with the PE line (mean difference 17.0 [95% CI 11.8-22.2] mmHg; p < .0001). The increase in intraluminal pressures was significantly higher with PE lines for both delayed and immediate connection when compared to the PVC lines (mean difference 29.5 [95% CI 19.3-39.7] mmHg; p < .0001). Related fluid volumes delivered at 10 s and 360 s after starting the pump ranged from -252% to 1321% (10 s) of expected infusion volumes and from 59% to 129% (360 s), respectively.

Conclusions: Both, timing of infusion line connection after purging and infusion line characteristics considerably affect intraluminal pressures and start-up fluid delivery when connecting a new syringe infusion pump assembly to a closed stopcock. Consecutive alterations in drug administration can have considerable hemodynamic consequences when dealing with catecholamine infusions in critically ill patients.

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输液管连接和输液管特性对用于微量输液的注射输液泵启动输液的影响。

背景：目的：本研究旨在评估不同条件下的加压程度及其对启动输液的影响：方法：使用聚氯乙烯（PVC）或聚乙烯（PE）制成的两种不同输液管，在连接输液管 1 分钟（延迟连接）或吹扫后立即连接（立即连接）的情况下，以 1 mL/h 的流速对腔内压力和启动输液进行评估：延迟连接导致 PVC 输液管的管腔内压力从零升高至 5.1 [4.5 至 5.7] mmHg，PE 输液管的管腔内压力从零升高至 47.1 [44.8 至 49.3] mmHg（平均差 42.0 [95% CI 39.3-44.7] mmHg；p 结论：两种输液管的连接时间不同：在将新的注射器输液泵组件连接到封闭的止塞时，吹扫后连接输液管路的时间和输液管路的特性都会对管腔内压力和启动输液造成很大影响。在危重病人输注儿茶酚胺时，连续改变给药方式会对血液动力学产生重大影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Anesthesia 医学-麻醉学

CiteScore

3.20

自引率

11.80%

发文量

222

审稿时长

3-8 weeks

期刊介绍： Devoted to the dissemination of research of interest and importance to practising anesthetists everywhere, the scientific and clinical content of Pediatric Anesthesia covers a wide selection of medical disciplines in all areas relevant to paediatric anaesthesia, pain management and peri-operative medicine. The International Editorial Board is supported by the Editorial Advisory Board and a team of Senior Advisors, to ensure that the journal is publishing the best work from the front line of research in the field. The journal publishes high-quality, relevant scientific and clinical research papers, reviews, commentaries, pro-con debates, historical vignettes, correspondence, case presentations and book reviews.