Use of HSP105 in the Differential Diagnosis of Basaloid Skin Tumors: A Study of 73 Cases.

IF 1.3 4区医学 Q3 ANATOMY & MORPHOLOGY

Applied Immunohistochemistry & Molecular Morphology Pub Date : 2024-10-01 Epub Date: 2024-10-08 DOI:10.1097/PAI.0000000000001224

Li-Jia Deng, Kai-Yi Zhou, Qin-Xiao Wang, Si-Yu Luo, Sheng Fang

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引用次数: 0

Abstract

Background: Basaloid skin tumors include subtypes of basal cell carcinoma (BCC) and the basaloid variant of squamous cell carcinoma (SCC). Due to their similarity in pathology and clinical presentation, their diagnosis is not straightforward. The aim of this study was to analyze the immunohistochemical expression of HSP105 in basaloid skin tumors, which include BCC, basosquamous carcinoma (BSC), metatypical basal cell carcinoma (MBCC), basaloid squamous cell carcinoma (BSCC), BCC with squamous differentiation as well as conventional SCC.

Methods: This retrospective study included 17 cases of BCC, 11 cases of BSC, 8 instances of MBCC, 10 cases of BCC with squamous differentiation, 8 cases of BSCC, and 19 cases of SCC. Their clinical characteristics were summarized, and the paraffin blocks of tumor biopsy specimens were collected for HSP105 immunostaining.

Results: In contrast to the BCC group, which stained predominantly negative, SCC stained diffusely positive for HSP105. BSCs showed some areas of HSP105 positivity with a transitional expression signature. HSP105 was only weakly positive in a few cases of MBCC. Although BSCC was stained positive for HSP105, the HSCORE was significantly lower than that of the classic SCC. In BCC with squamous differentiation, focal staining for HSP105 was only seen in the area of squamous differentiation.

Conclusion: There was a difference in immunohistochemical staining of HSP105 in basaloid skin tumors which helps in differential diagnosis. Differentiation between BCC, SCC, BSCC, MBCC, and BCC with squamous differentiation can be aided by immunohistochemistry using HSP105.

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HSP105 在基底样皮肤肿瘤鉴别诊断中的应用：73 个病例的研究

背景：基底样皮肤肿瘤包括基底细胞癌（BCC）的亚型和鳞状细胞癌（SCC）的基底样变型。由于病理和临床表现相似，它们的诊断并不简单。本研究旨在分析 HSP105 在基底型皮肤肿瘤（包括 BCC、基底鳞状细胞癌（BSC）、扁平基底细胞癌（MBCC）、基底鳞状细胞癌（BSCC）、鳞状分化 BCC 以及传统 SCC）中的免疫组化表达：这项回顾性研究包括 17 例 BCC、11 例 BSC、8 例 MBCC、10 例鳞状分化 BCC、8 例 BSCC 和 19 例 SCC。总结了他们的临床特征，并收集了肿瘤活检标本的石蜡块进行HSP105免疫染色：结果：与 BCC 组主要呈阴性相比，SCC 组的 HSP105 呈弥漫性阳性。BSC显示出一些HSP105阳性区域，具有过渡表达特征。在少数 MBCC 病例中，HSP105 仅呈弱阳性。虽然BSCC的HSP105染色呈阳性，但其HSCORE明显低于典型的SCC。在有鳞状分化的 BCC 中，HSP105 的局灶性染色仅见于鳞状分化区：结论：基底层皮肤肿瘤的 HSP105 免疫组化染色存在差异，有助于鉴别诊断。使用 HSP105 进行免疫组化有助于鉴别 BCC、SCC、BSCC、MBCC 和鳞状分化 BCC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY

CiteScore

3.20

自引率

0.00%

发文量

153

期刊介绍： Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology.