Association between gout and kidney stone: results from mendelian randomization and the NHANES study.

IF 2.8 3区生物学 Q2 GENETICS & HEREDITY

Frontiers in Genetics Pub Date : 2024-10-24 eCollection Date: 2024-01-01 DOI:10.3389/fgene.2024.1417663

Shengkai Jin, Haochen Geng, Yichen Lu, Yuhua Zhou, Jing Lv, Chaowei Fu, Yuwei Zhang, Menglu Li, Ninghan Feng

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引用次数: 0

Abstract

Background: Kidney stones are a common urologic disease with an increasing incidence year by year, and there are similar influences between gout status and kidney stone incidence. Therefore the contribution of gout status to the incidence of kidney stones is unclear. The aim of this study was to investigate the relationship between gout status and kidney stones and to further explore the causal relationship by Mendelian randomization (MR) analysis.

Method: An epidemiologic study of 49,693 participants in the 2009-2018 National Health and Nutrition Examination Survey (NHANES) was conducted to examine the association between the two. The causal relationship between gout status and kidney stones was assessed by Mendelian randomization analysis of data from the GWAS database.

Result: A total of 28,742 participants were included in the NHANES analysis. We found that gout status was associated with an increased risk of kidney stones [odds ratio (OR) = 1.45 (95%CI, 1.243-1.692); p < 0.001]. In the MR analysis, we found a causal relationship between gout status and the risk of developing kidney stones (OR = 1.047, 95%CI, 1.011-1.085, p = 0.009).

Conclusion: There may be an association between gout status and kidney stone risk. This finding requires further large-sample studies and adequate follow-up.

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痛风与肾结石之间的关系：亡羊补牢式随机化和 NHANES 研究的结果。

背景：肾结石是一种常见的泌尿系统疾病，发病率逐年上升，而痛风状况与肾结石发病率之间存在相似的影响因素。因此，痛风状况对肾结石发病率的影响尚不明确。本研究旨在调查痛风状况与肾结石之间的关系，并通过孟德尔随机分析法（MR）进一步探讨两者之间的因果关系：方法：对2009-2018年美国国家健康与营养调查（NHANES）中的49693名参与者进行流行病学研究，探讨两者之间的关系。通过对GWAS数据库中的数据进行孟德尔随机分析，评估痛风状况与肾结石之间的因果关系：共有 28,742 名参与者参与了 NHANES 分析。我们发现，痛风状态与肾结石风险的增加有关[几率比（OR）= 1.45（95%CI，1.243-1.692）；P < 0.001]。在 MR 分析中，我们发现痛风状态与患肾结石的风险之间存在因果关系（OR = 1.047，95%CI，1.011-1.085，p = 0.009）：结论：痛风状态与肾结石风险之间可能存在关联。结论：痛风状态与肾结石风险之间可能存在关联，这一发现需要进一步的大样本研究和充分的随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Genetics Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

5.50

自引率

8.10%

发文量

3491

审稿时长

14 weeks

期刊介绍： Frontiers in Genetics publishes rigorously peer-reviewed research on genes and genomes relating to all the domains of life, from humans to plants to livestock and other model organisms. Led by an outstanding Editorial Board of the world’s leading experts, this multidisciplinary, open-access journal is at the forefront of communicating cutting-edge research to researchers, academics, clinicians, policy makers and the public. The study of inheritance and the impact of the genome on various biological processes is well documented. However, the majority of discoveries are still to come. A new era is seeing major developments in the function and variability of the genome, the use of genetic and genomic tools and the analysis of the genetic basis of various biological phenomena.