Role and Interplay of Different Signaling Pathways Involved in Sciatic Nerve Regeneration

IF 2.8 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Molecular Neuroscience Pub Date : 2024-11-12 DOI:10.1007/s12031-024-02286-4

Saeedeh Zare Jalise, Sina Habibi, Leyla Fath-Bayati, Mohammad Amin Habibi, Shima Ababzadeh, Faezeh Hosseinzadeh

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引用次数: 0

Abstract

Regeneration of the sciatic nerve is a sophisticated process that involves the interplay of several signaling pathways that orchestrate the cellular responses critical to regeneration. Among the key pathways are the mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/AKT, cyclic adenosine monophosphate (cAMP), and Janus kinase/signal transducers and transcription activators (JAK/STAT) pathways. In particular, the cAMP pathway modulates neuronal survival and axonal regrowth. It influences various cellular behaviors and gene expression that are essential for nerve regeneration. MAPK is indispensable for Schwann cell differentiation and myelination, whereas PI3K/AKT is integral to the transcription, translation, and cell survival processes that are vital for nerve regeneration. Furthermore, GTP-binding proteins, including those of the Ras homolog gene family (Rho), regulate neural cell adhesion, migration, and survival. Notch signaling also appears to be effective in the early stages of nerve regeneration and in preventing skeletal muscle fibrosis after injury. Understanding the intricate mechanisms and interactions of these pathways is vital for the development of effective therapeutic strategies for sciatic nerve injuries. This review underscores the need for further research to fill existing knowledge gaps and improve therapeutic outcomes.

Graphical Abstract

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参与坐骨神经再生的不同信号通路的作用和相互作用

坐骨神经的再生是一个复杂的过程，涉及多个信号通路的相互作用，这些信号通路协调着对再生至关重要的细胞反应。其中的关键途径包括丝裂原活化蛋白激酶（MAPK）、磷脂酰肌醇 3-激酶（PI3K）/AKT、环磷酸腺苷（cAMP）和 Janus 激酶/信号转导和转录激活因子（JAK/STAT）途径。其中，cAMP 通路调节神经元的存活和轴突再生。它影响神经再生所必需的各种细胞行为和基因表达。MAPK 是许旺细胞分化和髓鞘化不可或缺的因素，而 PI3K/AKT 则是转录、翻译和细胞存活过程中不可或缺的因素，对神经再生至关重要。此外，GTP 结合蛋白，包括 Ras 同源基因家族（Rho）的蛋白，可调节神经细胞的粘附、迁移和存活。Notch 信号在神经再生的早期阶段和防止骨骼肌损伤后纤维化方面似乎也很有效。了解这些通路的复杂机制和相互作用对于开发有效的坐骨神经损伤治疗策略至关重要。本综述强调了进一步研究的必要性，以填补现有的知识空白并改善治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Neuroscience 医学-神经科学

CiteScore

6.60

自引率

3.20%

发文量

142

审稿时长

1 months

期刊介绍： The Journal of Molecular Neuroscience is committed to the rapid publication of original findings that increase our understanding of the molecular structure, function, and development of the nervous system. The criteria for acceptance of manuscripts will be scientific excellence, originality, and relevance to the field of molecular neuroscience. Manuscripts with clinical relevance are especially encouraged since the journal seeks to provide a means for accelerating the progression of basic research findings toward clinical utilization. All experiments described in the Journal of Molecular Neuroscience that involve the use of animal or human subjects must have been approved by the appropriate institutional review committee and conform to accepted ethical standards.