Cellular mechanisms of combining innate immunity activation with PD-1/PD-L1 blockade in treatment of colorectal cancer

IF 6.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL
Qi Xie, Xiaolin Liu, Rengyun Liu, Jingxuan Pan, Jing Liang
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引用次数: 0

Abstract

PD-1/PD-L1 blockade therapies have displayed extraordinary clinical efficacy for melanoma, renal, bladder and lung cancer; however, only a minority of colorectal cancer (CRC) patients benefit from these treatments. The efficacy of PD-1/PD-L1 blockade in CRC is limited by the complexities of tumor microenvironment. PD-1/PD-L1 blockade immunotherapy is based on T cell-centered view of tumor immunity. However, the onset and maintenance of T cell responses and the development of long-lasting memory T cells depend on innate immune responses. Acknowledging the pivotal role of innate immunity in anti-tumor immune response, this review encapsulates the employment of combinational therapies those involve PD-1/PD-L1 blockade alongside the activation of innate immunity and explores the underlying cellular mechanisms, aiming to harnessing innate immune responses to induce long-lasting tumor control for CRC patients who received PD-1/PD-L1 blockade therapy.
先天性免疫激活与 PD-1/PD-L1 阻断相结合治疗结直肠癌的细胞机制
PD-1/PD-L1阻断疗法对黑色素瘤、肾癌、膀胱癌和肺癌显示出非凡的临床疗效;然而,只有少数结直肠癌(CRC)患者能从这些疗法中获益。由于肿瘤微环境的复杂性,PD-1/PD-L1 阻断疗法对 CRC 的疗效受到了限制。PD-1/PD-L1 阻断免疫疗法是基于以 T 细胞为中心的肿瘤免疫观点。然而,T 细胞应答的发生和维持以及长效记忆 T 细胞的形成都依赖于先天性免疫应答。鉴于先天性免疫在抗肿瘤免疫反应中的关键作用,本综述总结了在激活先天性免疫的同时使用 PD-1/PD-L1 阻断的联合疗法,并探讨了其潜在的细胞机制,旨在利用先天性免疫反应为接受 PD-1/PD-L1 阻断疗法的 CRC 患者诱导持久的肿瘤控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Analytical Chemistry
Analytical Chemistry 化学-分析化学
CiteScore
12.10
自引率
12.20%
发文量
1949
审稿时长
1.4 months
期刊介绍: Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.
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