Mef2d: a novel transcription factor in type 2 allergic lung inflammation

Abstract

In a recent article published in Science, Szeto et al. identified myocyte-specific enhancer factor 2d (Mef2d) as a promoter of type 2 immunity and allergic lung inflammation. Using CRISPR screens and orthogonal recombinase-enabled Boolean gene circuitry, the authors revealed that Mef2d modulates GATA3 expression by suppressing Regnase-1, thereby boosting IL-33 signaling and cytokine production.¹