Depression and obesity: Focus on factors and mechanistic links

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-11-04 DOI:10.1016/j.bbadis.2024.167561

Ashley Selman , Jean Dai , Jackson Driskill , Arubala P. Reddy , P. Hemachandra Reddy

{"title":"Depression and obesity: Focus on factors and mechanistic links","authors":"Ashley Selman , Jean Dai , Jackson Driskill , Arubala P. Reddy , P. Hemachandra Reddy","doi":"10.1016/j.bbadis.2024.167561","DOIUrl":null,"url":null,"abstract":"<div><div>Major depressive disorder (MDD) is defined as mood disorder causing a persistent loss of interest and despair for two weeks or greater, with related symptoms. Depression can interfere with daily life and can cause those affected to not work, study, eat, sleep, and enjoy previously enjoyed hobbies and life events as they did previously. If untreated, it can become a serious health condition. Depression is multifactorial with a variety of factors influencing the condition. These factors include: (1) poor diet and exercise, (2) socioeconomic status, (3) gender, (4) biological clocks, (5) genetics and epigenetics, and (6) personal stressors. Treatment of depressive disorders is thus also multifactorial and utilizes the following therapies: (1) diet and exercise, (2) bright light therapy, (3) cognitive behavioral therapy, and (4) pharmaceutical therapy. Obesity is defined as body mass index over 30 and above, is believed to be causally linked to MDD through both psychological and molecular means. Atypical depression, a common form of MDD, is most strongly correlated with a high proclivity for obesity. Obesity and depression have a bidirectional relationship, a patient experiencing either condition singularly is more likely to develop the other due to the neural links between the two, including emotional lability, physical health of the brain, hormones, cytokine secretion, appetite, diet and feeding habits, inflammatory state. In individuals consuming a high fat diet (HFD) commonly ingested by those with obesity, the gut-microbiome is altered leading to systemic inflammation and the dysregulation of mood and the HPA axis impacting their neural health. The purpose of this paper is to examine the interplay of potential molecular, psychological, societal, and environmental causal factors of depressive disorders and how obesity perpetuates depression. A secondary aim of this paper is to examine current interventions that may help improve those affected by both conditions.</div></div>","PeriodicalId":8821,"journal":{"name":"Biochimica et biophysica acta. Molecular basis of disease","volume":"1871 1","pages":"Article 167561"},"PeriodicalIF":4.2000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et biophysica acta. Molecular basis of disease","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0925443924005556","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Major depressive disorder (MDD) is defined as mood disorder causing a persistent loss of interest and despair for two weeks or greater, with related symptoms. Depression can interfere with daily life and can cause those affected to not work, study, eat, sleep, and enjoy previously enjoyed hobbies and life events as they did previously. If untreated, it can become a serious health condition. Depression is multifactorial with a variety of factors influencing the condition. These factors include: (1) poor diet and exercise, (2) socioeconomic status, (3) gender, (4) biological clocks, (5) genetics and epigenetics, and (6) personal stressors. Treatment of depressive disorders is thus also multifactorial and utilizes the following therapies: (1) diet and exercise, (2) bright light therapy, (3) cognitive behavioral therapy, and (4) pharmaceutical therapy. Obesity is defined as body mass index over 30 and above, is believed to be causally linked to MDD through both psychological and molecular means. Atypical depression, a common form of MDD, is most strongly correlated with a high proclivity for obesity. Obesity and depression have a bidirectional relationship, a patient experiencing either condition singularly is more likely to develop the other due to the neural links between the two, including emotional lability, physical health of the brain, hormones, cytokine secretion, appetite, diet and feeding habits, inflammatory state. In individuals consuming a high fat diet (HFD) commonly ingested by those with obesity, the gut-microbiome is altered leading to systemic inflammation and the dysregulation of mood and the HPA axis impacting their neural health. The purpose of this paper is to examine the interplay of potential molecular, psychological, societal, and environmental causal factors of depressive disorders and how obesity perpetuates depression. A secondary aim of this paper is to examine current interventions that may help improve those affected by both conditions.

查看原文本刊更多论文

抑郁症与肥胖症：关注因素和机理联系。

重度抑郁障碍（MDD）被定义为情绪障碍，导致持续两周或更长时间的兴趣丧失和绝望，并伴有相关症状。抑郁症会影响日常生活，使患者无法像以前那样工作、学习、吃饭、睡觉、享受以前喜欢的爱好和生活活动。如果不及时治疗，抑郁症可能会成为一种严重的健康问题。抑郁症是一种多因素疾病，受多种因素影响。这些因素包括(1) 不良饮食和运动，(2) 社会经济地位，(3) 性别，(4) 生物钟，(5) 遗传学和表观遗传学，以及 (6) 个人压力。因此，抑郁障碍的治疗也是多因素的，可采用以下疗法：（1）饮食和运动疗法；（2）强光疗法；（3）认知行为疗法；（4）药物疗法。肥胖是指体重指数超过 30 及以上，据信通过心理和分子手段与多发性抑郁症有因果关系。非典型抑郁症是 MDD 的一种常见形式，与肥胖的高度倾向性关系最为密切。肥胖与抑郁症之间存在双向关系，由于二者之间的神经联系，包括情绪不稳定、大脑的身体健康、激素、细胞因子分泌、食欲、饮食习惯、炎症状态等，单独患有其中一种疾病的患者更有可能患上另一种疾病。肥胖症患者通常摄入高脂肪饮食（HFD），肠道微生物组发生改变，导致全身炎症、情绪失调和 HPA 轴影响神经健康。本文旨在研究抑郁症的潜在分子、心理、社会和环境致病因素之间的相互作用，以及肥胖如何使抑郁症长期存在。本文的另一个目的是研究目前可能有助于改善受这两种疾病影响的人的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biochimica et biophysica acta. Molecular basis of disease 生物-生化与分子生物学

CiteScore

12.30

自引率

0.00%

发文量

218

审稿时长

32 days

期刊介绍： BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. The submission of uninvited reviews to BBA - Molecular Basis of Disease is strongly discouraged, and any such uninvited review should be accompanied by a coverletter outlining the compelling reasons why the review should be considered.