Segmental abnormalities of white matter microstructure in multiple sclerosis and neuromyelitis optica spectrum disorder identified by automated fiber quantification

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2024-10-29 DOI:10.1016/j.msard.2024.106147

Yan Xie, Shaolong Wu, Houming Su, Yihao Yao, Hongquan Zhu, Yan Zhang, Wenzhen Zhu

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引用次数: 0

Abstract

Background

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are different in pathogenesis, but both could lead to white matter (WM) microstructural damage. The aim of this study was to explore the differences in the patterns of WM fiber tract damage in relapsing-remitting MS (RRMS) and NMOSD by automated fiber quantification (AFQ).

Materials and Methods

Forty-one RRMS patients, 30 NMOSD patients and 30 healthy controls (HC) underwent MRI examination. AFQ was applied to identify and quantify 100 equally spaced nodes of specific WM fiber tracts for each participant. Measurements of fractional anisotropy (FA), mean diffusion (MD), axial diffusivity (AD) and radial diffusivity (RD) for each segment of a specific fiber tract were compared between RRMS, NMOSD and HC.

Results

The decrease in FA was found in 7 fiber tracts in entire tract comparison and 9 fiber tracts in pointwise comparison in RRMS patients. However, the FA in left thalamic radiation (TR) and right uncinate fasciculus showed significant differences between RRMS and HC only in the pointwise comparison, but not in the entire tract comparison. The MD, AD and RD of WM fiber tracts in RRMS patients were extensively increased both in the entire level and in the pointwise level. NMOSD patients showed significant FA decrease in left TR and callosum forceps minor (CF_minor), and significant RD increase in CF_minor in the pointwise level. In the pointwise comparison between RRMS and NMOSD, significant FA decrease was found in right inferior fronto-occipital fasciculus and bilateral inferior longitudinal fasciculus in RRMS patients, focal or widespread MD, AD and RD increase was found in multiple fiber tracts.

Conclusion

The AFQ approach is a more sensitive way to reflect WM microstructural abnormalities, revealing extensive WM microstructural damage in RRMS and limited WM fiber tract damage in NMOSD.

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通过自动纤维量化技术识别多发性硬化症和神经性脊髓炎谱系障碍中白质微观结构的节段性异常

背景多发性硬化症（MS）和神经脊髓炎视神经频谱疾病（NMOSD）的发病机制不同，但都可能导致白质（WM）微结构损伤。本研究旨在通过自动纤维定量法（AFQ）探讨复发性多发性硬化症（RRMS）和神经性视网膜炎谱系障碍（NMOSD）白质纤维束损伤模式的差异。应用自动纤维定量法识别并量化了每位受试者特定 WM 纤维束的 100 个等间距节点。结果在整个纤维束比较中发现RRMS患者7个纤维束的FA下降，在点状比较中发现9个纤维束的FA下降。然而，RRMS和HC之间左丘脑辐射（TR）和右钩状束的FA仅在点状比较中显示出显著差异，而在整束比较中未显示出显著差异。RRMS患者WM纤维束的MD、AD和RD在整个水平和点水平上都广泛增加。NMOSD患者左侧TR和胼胝体小肌（CF_minor）的FA显著降低，而CF_minor的RD在点状水平上显著增加。在RRMS和NMOSD的点状比较中，发现RRMS患者右侧下额枕筋束和双侧下纵筋束的FA显著降低，多个纤维束中发现局灶性或广泛性的MD、AD和RD增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.