Advances in mRNA vaccine research in the field of quality control

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-11-01 DOI:10.1016/j.biologicals.2024.101799

Daomiao Huang , Na Li , Xin Dong

引用次数: 0

Abstract

In recent years, innovative research and development of mRNA vaccines have made remarkable achievements, especially in the context of pandemic infectious diseases such as the COVID-19 virus, and the need for rapid vaccine development has further fueled the rapid growth of this field. Nevertheless, there are still gaps in our understanding of the working mechanism of mRNA vaccines and their long-term safety, efficacy, and quality control. This article summarizes the development background and production process of mRNA vaccines, outlines existing reference guidelines, quality control projects, and testing methods at home and abroad, and also summarizes the difficulties and future prospects in research and development and quality control. It provides a reference for developing guidelines for mRNA vaccine production, quality control, and preclinical and clinical evaluation.

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质量控制领域的 mRNA 疫苗研究进展

近年来，mRNA 疫苗的创新研究和开发取得了令人瞩目的成就，尤其是在 COVID-19 病毒等大流行传染病的背景下，对疫苗快速开发的需求进一步推动了这一领域的快速发展。然而，我们对 mRNA 疫苗的工作机制及其长期安全性、有效性和质量控制的认识仍有差距。本文总结了 mRNA 疫苗的发展背景和生产过程，概述了国内外现有的参考指南、质量控制项目和检测方法，并总结了研发和质量控制方面的困难和未来展望。它为制定 mRNA 疫苗生产、质量控制以及临床前和临床评估指南提供了参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.