Vitamin D deficiency in pediatric sickle cell disease patients without crisis - A cry to investigate it on priority.

IF 2 Q2 MEDICINE, GENERAL & INTERNAL
Shahida Aziz Khan, Torki Al Zughaibi, Sarah A Khan
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Abstract

Objective: The alarming increase in vitamin D deficiency (VDD) has been shown to result in compounded risks of major health problems globally. As sickle cell disease (SCD) children are already health compromised, the co-morbidities escalate early in life, demanding an early detection, to minimize the adverse effects. This study determined vitamin D levels in children with SCD without a crisis to check for probable associations with inflammation and infections if any.

Methods: SCD children aged 5-16 years, in a steady state, were enrolled in the study after taking necessary consent and ethical clearance. Hb, serum calcium, vitamin D, and high-sensitivity C-reactive protein (hsCRP) levels were analyzed.

Results: VDD was seen in most of the children with SCD irrespective of gender and age. Males aged 5-10 years showed significance (P = 0.0375) with vitamin D and white blood cell (WBC) (P = 0.0015) but males aged 11-16-year age group exhibited a very strong-positive correlation with vitamin D (r = 0.9862) and a very strong-negative correlation with Hb (r = -0.9819) and hsCRP (r = -0.9907). Among females, the 11-16-year age group patients exhibited a significant association with vitamin D (P = 0.0487), Ca (P = 0.0118), Hb (P = 0.0007), and hsCRP (P = 0.0001) levels. Correlation "r" values in this age group show a strong-negative correlation with WBC levels (r = -0.6525) as well as hsCRP (r = - 0.6550).

Conclusion: The increased deficiency of vitamin D in SCD children should be addressed at early ages of life, to reduce the occurrence and severity of associated comorbidities.

小儿镰状细胞病患者缺乏维生素 D,但未出现危机--呼吁优先研究这一问题。
目的:维生素 D 缺乏症(VDD)的惊人增长已在全球范围内导致重大健康问题的复合风险。由于镰状细胞病(SCD)患儿的健康状况已经受到损害,其并发症在生命早期就会增加,因此需要及早发现,以尽量减少不良影响。本研究测定了未发生危机的 SCD 儿童的维生素 D 水平,以检查是否可能与炎症和感染有关:方法:在征得必要的同意并通过伦理审查后,将 5-16 岁处于稳定状态的 SCD 儿童纳入研究。对血红蛋白、血清钙、维生素 D 和高敏 C 反应蛋白(hsCRP)水平进行了分析:结果:大多数 SCD 患儿都出现了 VDD,与性别和年龄无关。5-10 岁的男性与维生素 D 和白细胞(WBC)(P = 0.0015)呈显著相关(P = 0.0375),但 11-16 岁年龄组的男性与维生素 D 呈极强的正相关(r = 0.9862),而与血红蛋白(r = -0.9819)和高敏 C 反应蛋白(hsCRP)(r = -0.9907)呈极强的负相关。在女性患者中,11-16 岁年龄组患者与维生素 D(P = 0.0487)、Ca(P = 0.0118)、Hb(P = 0.0007)和 hsCRP(P = 0.0001)水平有显著相关性。该年龄组的相关 "r "值与白细胞水平(r = -0.6525)和 hsCRP(r = - 0.6550)呈强负相关:结论:SCD 儿童维生素 D 缺乏症的增加应在生命早期得到解决,以减少相关并发症的发生和严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Health Sciences-IJHS
International Journal of Health Sciences-IJHS MEDICINE, GENERAL & INTERNAL-
自引率
15.00%
发文量
49
审稿时长
8 weeks
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