Elevation of serum neurofilament light-chain levels disclose possible occult progressive multifocal leukoencephalopathy and immune reconstitution syndrome in a patient receiving ozanimod: a case report.

IF 5.7 2区医学 Q1 IMMUNOLOGY

Frontiers in Immunology Pub Date : 2024-10-22 eCollection Date: 2024-01-01 DOI:10.3389/fimmu.2024.1465678

Carlos Quintanilla-Bordás, David Gorriz, Laura Cubas-Núñez, Jéssica Castillo-Villalba, Joan Carreres-Polo, Bonaventura Casanova, Francisco Carlos Pérez-Miralles

{"title":"Elevation of serum neurofilament light-chain levels disclose possible occult progressive multifocal leukoencephalopathy and immune reconstitution syndrome in a patient receiving ozanimod: a case report.","authors":"Carlos Quintanilla-Bordás, David Gorriz, Laura Cubas-Núñez, Jéssica Castillo-Villalba, Joan Carreres-Polo, Bonaventura Casanova, Francisco Carlos Pérez-Miralles","doi":"10.3389/fimmu.2024.1465678","DOIUrl":null,"url":null,"abstract":"Background: We report the first case of findings suggestive of progressive multifocal leukoencephalopathy and immune restitution syndrome (PML-IRIS) in a patient with multiple sclerosis receiving ozanimod preceded by an unexpected increase in the serum neurofilament light-chain (sNfL) levels.Case report: A 57-year-old-woman treated with ozanimod for the last 8 years presented, during surveillance MRI, with findings compatible with PML-IRIS. Overt clinical symptoms were absent. sNfL levels increased 4 months earlier and peaked at presentation. Lymphocyte count reached nadir of 330/mL at 8 months earlier.Conclusion: The case illustrates the utility of sNfL levels for PML surveillance in patients receiving immunosuppressors.","PeriodicalId":12622,"journal":{"name":"Frontiers in Immunology","volume":null,"pages":null},"PeriodicalIF":5.7000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535851/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fimmu.2024.1465678","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: We report the first case of findings suggestive of progressive multifocal leukoencephalopathy and immune restitution syndrome (PML-IRIS) in a patient with multiple sclerosis receiving ozanimod preceded by an unexpected increase in the serum neurofilament light-chain (sNfL) levels.

Case report: A 57-year-old-woman treated with ozanimod for the last 8 years presented, during surveillance MRI, with findings compatible with PML-IRIS. Overt clinical symptoms were absent. sNfL levels increased 4 months earlier and peaked at presentation. Lymphocyte count reached nadir of 330/mL at 8 months earlier.

Conclusion: The case illustrates the utility of sNfL levels for PML surveillance in patients receiving immunosuppressors.

查看原文本刊更多论文

一名接受奥扎莫德治疗的患者血清神经丝轻链水平升高，显示可能存在隐匿性进行性多灶性白质脑病和免疫重建综合征：病例报告。

背景：我们报告了首例提示进行性多灶性白质脑病和免疫恢复综合征（PML-IRIS）的病例，该病例是一名接受奥扎莫德治疗的多发性硬化症患者，发病前血清神经丝轻链（sNfL）水平意外升高：病例报告：一名 57 岁的女性患者在过去 8 年中一直接受奥扎莫德治疗，在接受磁共振成像监测时发现与 PML-IRIS 相吻合的结果。4个月前，sNfL水平升高，发病时达到峰值。淋巴细胞计数在 8 个月前达到 330 个/毫升的最低点：本病例说明了在接受免疫抑制剂治疗的患者中使用 sNfL 水平监测 PML 的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Immunology IMMUNOLOGY-

CiteScore

9.80

自引率

11.00%

发文量

7153

审稿时长

14 weeks

期刊介绍： Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.