Claudin-5 and occludin levels in patients with psychiatric disorders − A systematic review

IF 8.8 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2024-11-03 DOI:10.1016/j.bbi.2024.11.006

Zinovia Maridaki , Georgios Syrros , Stella Gianna Delichatsiou , Jerry Warsh , Gerasimos N. Konstantinou

{"title":"Claudin-5 and occludin levels in patients with psychiatric disorders − A systematic review","authors":"Zinovia Maridaki , Georgios Syrros , Stella Gianna Delichatsiou , Jerry Warsh , Gerasimos N. Konstantinou","doi":"10.1016/j.bbi.2024.11.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Recent research has underscored the critical role of blood–brain barrier (BBB) integrity in psychiatric disorders, highlighting disruptions in tight junction (TJ) proteins, specifically claudin-5 and occludin. These proteins are pivotal in maintaining the BBB’s selective permeability, which is essential forbrain homeostasis. Altered levels of the TJ proteins have been observed in various psychiatric conditions, suggesting potential as biomarkers for the pathophysiology of these disorders. This systematic review synthesizes existing research on the alterations of claudin-5 and occludin levels in the serum of individuals with psychiatric disorders, evaluating their correlation with BBB dysfunction and psychiatric pathophysiology.</div></div><div><h3>Methods</h3><div>In adherence to the PRISMA guidelines, a comprehensive search strategy was employed, utilizing databases such as PubMed, Google Scholar, Web of Science, and Scopus. The review encompassed studies published between 2000 and 2024 that measured serum claudin-5 and occludin levels of psychiatric patients. Thorough data extraction and synthesis were conducted.</div></div><div><h3>Results</h3><div>Seventeen studies met the inclusion criteria. Key findings include indications for increased claudin-5 levels in Schizophrenia, Bipolar Disorder, Depression, and Specific learning disorder, and increased occludin levels in ADHD and Autism Spectrum Disorder patients. No significant differences were found in studies of patients with Alcohol Use and Insomnia Disorder.</div></div><div><h3>Conclusions</h3><div>The review underscores the potential association between altered serum levels of claudin-5 and occludin and psychiatric disorders, supporting their utility as biomarkers for BBB integrity and psychiatric pathophysiology. Further research is essential to elucidate the mechanisms linking TJ protein alterations with pathophysiology and, potentially, neuroprogression in psychiatric disorders, which could lead to novel diagnostic and therapeutic strategies.</div></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":"123 ","pages":"Pages 865-875"},"PeriodicalIF":8.8000,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain, Behavior, and Immunity","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0889159124006895","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Recent research has underscored the critical role of blood–brain barrier (BBB) integrity in psychiatric disorders, highlighting disruptions in tight junction (TJ) proteins, specifically claudin-5 and occludin. These proteins are pivotal in maintaining the BBB’s selective permeability, which is essential for brain homeostasis. Altered levels of the TJ proteins have been observed in various psychiatric conditions, suggesting potential as biomarkers for the pathophysiology of these disorders. This systematic review synthesizes existing research on the alterations of claudin-5 and occludin levels in the serum of individuals with psychiatric disorders, evaluating their correlation with BBB dysfunction and psychiatric pathophysiology.

Methods

In adherence to the PRISMA guidelines, a comprehensive search strategy was employed, utilizing databases such as PubMed, Google Scholar, Web of Science, and Scopus. The review encompassed studies published between 2000 and 2024 that measured serum claudin-5 and occludin levels of psychiatric patients. Thorough data extraction and synthesis were conducted.

Results

Seventeen studies met the inclusion criteria. Key findings include indications for increased claudin-5 levels in Schizophrenia, Bipolar Disorder, Depression, and Specific learning disorder, and increased occludin levels in ADHD and Autism Spectrum Disorder patients. No significant differences were found in studies of patients with Alcohol Use and Insomnia Disorder.

Conclusions

The review underscores the potential association between altered serum levels of claudin-5 and occludin and psychiatric disorders, supporting their utility as biomarkers for BBB integrity and psychiatric pathophysiology. Further research is essential to elucidate the mechanisms linking TJ protein alterations with pathophysiology and, potentially, neuroprogression in psychiatric disorders, which could lead to novel diagnostic and therapeutic strategies.

查看原文本刊更多论文

精神病患者体内的 Claudin-5 和 occludin 水平 - 系统综述。

背景：最近的研究强调了血脑屏障（BBB）完整性在精神疾病中的关键作用，突出了紧密连接（TJ）蛋白，特别是克劳丁-5（claudin-5）和闭塞素（occludin）的破坏。这些蛋白在维持 BBB 的选择性通透性方面起着关键作用，而选择性通透性对于脑平衡至关重要。在各种精神疾病中都观察到了 TJ 蛋白水平的改变，这表明它们有可能成为这些疾病病理生理学的生物标记物。本系统性综述综合了有关精神疾病患者血清中 claudin-5 和 occludin 水平变化的现有研究，评估了它们与 BBB 功能障碍和精神疾病病理生理学的相关性：根据 PRISMA 指南，利用 PubMed、Google Scholar、Web of Science 和 Scopus 等数据库采用了综合检索策略。该综述涵盖了2000年至2024年间发表的测量精神病患者血清claudin-5和occludin水平的研究。对数据进行了彻底的提取和综合：结果：17 项研究符合纳入标准。主要发现包括精神分裂症、双相情感障碍、抑郁症和特殊学习障碍患者的 claudin-5 水平升高，多动症和自闭症谱系障碍患者的 occludin 水平升高。对酗酒和失眠症患者的研究未发现明显差异：本综述强调了血清中 claudin-5 和 occludin 水平的改变与精神疾病之间的潜在联系，支持它们作为 BBB 完整性和精神疾病病理生理学生物标志物的作用。进一步的研究对于阐明 TJ 蛋白改变与病理生理学以及精神疾病中潜在的神经发育之间的关联机制至关重要，这可能会带来新的诊断和治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.