Frequency and clinical characteristics of children and young people with type 2 diabetes at diagnosis from five world regions between 2012 and 2021: data from the SWEET Registry.

IF 8.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetologia Pub Date : 2025-01-01 Epub Date: 2024-11-06 DOI:10.1007/s00125-024-06283-5
Rosaria Gesuita, Alexander J Eckert, Stéphane Besançon, Nancy A Crimmins, Fred Cavallo, Jaehyun Kim, Craig Jefferies, Evelien F Gevers, Anastasios Vamvakis, Sejal Shah, Shazhan Amed, Valentino Cherubini
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引用次数: 0

Abstract

Aims/hypothesis: The diagnosis of type 2 diabetes is increasing in young people worldwide. This study evaluated the frequency and clinical characteristics of young people presenting with type 2 diabetes from the multinational SWEET e.V Registry 2012-2021, including the first years of the COVID-19 pandemic.

Methods: This is a longitudinal observational study based on the SWEET Registry, which collects demographic and clinical data on children and adolescents with diabetes from centres worldwide, with the diagnosis and classification of diabetes provided locally by each centre according to International Society for Paediatric and Adolescent Diabetes definitions. By July 2022, the SWEET Registry included 96,931 individuals from 130 centres with a total of 1,154,555 visits. Data were analysed by region: Europe (EU), Australia and New Zealand (AU/NZ), South America (SA), North America (NA) and Asia/Middle East and Africa (AS/AF). Trends in proportions for the two-year periods, calculated as cases with type 2 diabetes diagnoses over all cases with diabetes diagnoses, were estimated using logistic regression models adjusted for age at onset and sex.

Results: Overall, there were 2819 of 58,170 new cases (4.8%) with type 2 diabetes: 614 in EU, 293 in AU/NZ, 79 in SA, 1211 in NA and 622 in AS/AF. The proportion of type 2 diabetes increased from 3.2% to 6.0% from 2012/2013 to 2020/2021, a relative rate of increase of 9% per two-year period (95% CI 5.9, 12.3; p<0.001). In the two-year period of the COVID-19 pandemic, type 2 diabetes continued to follow the observed trend, with a proportion of 6.0% in 2020-2021 compared with 5.4% in 2018-2019. High variability in the proportion of type 2 diabetes was observed across regions, with the lowest values observed in EU and the highest in NA. A significant increase in the proportion of type 2 diabetes was observed in EU, AU/NZ and NA. The median HbA1c was not uniform and was highest in AS/AF (85 mmol/mol [9.9%]; IQR 55-111 [7.2-12.3%]) and lowest in EU (63 mmol/mol [7.9%]; IQR 48-99 [6.5-11.2%]), and the difference between EU and NA (median value 73 mmol/mol [8.8%]; IQR 50-105 [6.7-11.8%]) was statistically significant (p=0.047). There was also a difference in BMI SD score by region: the lowest median BMI SD score was 2.2 (IQR 1.4-2.7) in AS/AF and the highest was 3.1 (IQR 2.5-3.6) in AU/NZ.

Conclusions/interpretation: The multinational SWEET data from the years 2012 to 2021 inclusive support recent findings of a worldwide increase in type 2 diabetes in young people, albeit with regional differences. This increase highlights the need for ongoing preventive measures and available advanced treatment modalities worldwide.

Abstract Image

2012 年至 2021 年全球五大地区 2 型糖尿病儿童和青少年患者的诊断频率和临床特征:来自 SWEET 登记处的数据。
目的/假设:在全球范围内,确诊为 2 型糖尿病的年轻人越来越多。本研究评估了2012-2021年(包括COVID-19大流行的最初几年)跨国SWEET e.V登记处的2型糖尿病青少年患者的发病频率和临床特征:这是一项基于 SWEET 注册表的纵向观察研究,该注册表收集了来自全球各中心的儿童和青少年糖尿病患者的人口和临床数据,各中心根据国际儿童和青少年糖尿病学会的定义在当地对糖尿病进行诊断和分类。截至 2022 年 7 月,SWEET 注册中心共纳入了来自 130 个中心的 96931 名患者,访问总次数达 1154555 次。数据按地区进行分析:欧洲(EU)、澳大利亚和新西兰(AU/NZ)、南美洲(SA)、北美洲(NA)以及亚洲/中东和非洲(AS/AF)。使用逻辑回归模型估算了两年期间的比例趋势,计算方法是确诊为2型糖尿病的病例占所有确诊为糖尿病的病例的比例,并对发病年龄和性别进行了调整:总体而言,58170 例新病例中有 2819 例(4.8%)患有 2 型糖尿病:欧盟 614 例、澳大利亚/新西兰 293 例、南澳大利亚 79 例、北美洲 1211 例、澳大利亚/南非 622 例。从 2012/2013 年到 2020/2021 年,2 型糖尿病的比例从 3.2% 增加到 6.0%,每两年的相对增长率为 9%(95% CI 5.9,12.3;p1c 不一致,在 AS/AF 中最高(85 mmol/mol [9.9%];IQR 55.0,10.0%)。9%];IQR 55-111 [7.2-12.3%]),欧盟最低(63 mmol/mol [7.9%];IQR 48-99 [6.5-11.2%]),欧盟与 NA 之间的差异(中位值 73 mmol/mol [8.8%];IQR 50-105 [6.7-11.8%])具有统计学意义(P=0.047)。不同地区的 BMI SD 评分也存在差异:AS/AF 的 BMI SD 评分中位数最低为 2.2(IQR 1.4-2.7),最高为 3.1(IQR 2.5-3.6):2012年至2021年(含2021年)的多国SWEET数据支持了最近的研究结果,即全球年轻人2型糖尿病的发病率在上升,尽管存在地区差异。这一增长凸显了在全球范围内持续采取预防措施和先进治疗方法的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diabetologia
Diabetologia 医学-内分泌学与代谢
CiteScore
18.10
自引率
2.40%
发文量
193
审稿时长
1 months
期刊介绍: Diabetologia, the authoritative journal dedicated to diabetes research, holds high visibility through society membership, libraries, and social media. As the official journal of the European Association for the Study of Diabetes, it is ranked in the top quartile of the 2019 JCR Impact Factors in the Endocrinology & Metabolism category. The journal boasts dedicated and expert editorial teams committed to supporting authors throughout the peer review process.
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