La fibromialgia con factor reumatoide elevado se asocia a mala respuesta terapéutica pero no con progresión a artritis reumatoide. Estudio de cohortes prospectivo

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-11-01 DOI:10.1016/j.reuma.2024.06.005

Freddy Liñán Ponce, Juan Leiva Goicochea, David Sevilla Rodríguez, Elmer Hidalgo Bravo, Ginna Obregón Atanacio, Inés Loyola Macalapú, Paola Jáuregui Rojas, Jackeline Yampufe Canani

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Abstract

Objective

Evaluate response to treatment and progression to rheumatoid arthritis (RA) in patients with fibromyalgia (FM) associated with elevated rheumatoid factor (RF).

Material and methods

Prospective cohort study. The sample consisted of 124 patients with FM: 62 with high RF (> 20 U/ml) and 62 with negative RF (0-20 U/ml). All patients were evaluated using FM treatment improvement score (FIQR) and progression to RA according to EULAR/ACR 2010 criteria at 6 and 12 months. Pearson's χ² test for homogeneity was used to relate variables of improvement to FM treatment and progression to RA.

Results

The response to treatment was lower in the high RF group (24 and 20 patients improved at 6 and 12 months, respectively, compared to 45 and 38 patients in the negative RF group), with a significant difference. Progression to rheumatoid arthritis was similar in both groups (5 in the high RF group and 4 in the negative RF group), with a non-significant relationship.

Conclusions

FM with elevated RF is associated with a poor therapeutic response but not with progression to RA.

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类风湿因子升高的纤维肌痛与治疗反应不佳有关，但与发展为类风湿关节炎无关。前瞻性队列研究

目的评估类风湿因子（RF）升高的纤维肌痛（FM）患者对治疗的反应以及发展为类风湿关节炎（RA）的情况。样本包括 124 名 FM 患者：62 名 RF 偏高（> 20 U/ml），62 名 RF 偏低（0-20 U/ml）。根据 EULAR/ACR 2010 标准，使用 FM 治疗改善评分（FIQR）对所有患者进行评估，并在 6 个月和 12 个月后评估其是否进展为 RA。结果高RF组的治疗反应较低（6个月和12个月时分别有24名和20名患者好转，而阴性RF组分别有45名和38名患者好转），差异显著。两组患者进展为类风湿性关节炎的情况相似（高RF组5例，阴性RF组4例），但关系不显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.