Regulatory role of microRNAs in virus-mediated inflammation.

IF 4.4 3区医学 Q2 IMMUNOLOGY

Journal of Inflammation-London Pub Date : 2024-11-04 DOI:10.1186/s12950-024-00417-7

Hossein Bannazadeh Baghi, Mobina Bayat, Parisa Mehrasa, Seyed Mohammad Amin Alavi, Mohammad Hassan Lotfalizadeh, Mohammad Yousef Memar, Seyed Pouya Taghavi, Fatemeh Zarepour, Michael R Hamblin, Javid Sadri Nahand, Seyed Mohammad Reza Hashemian, Hamed Mirzaei

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引用次数: 0

Abstract

Viral infections in humans often cause excessive inflammation. In some viral infections, inflammation can be serious and even fatal, while in other infections it can promote viral clearance. Viruses can escape from the host immune system via regulating inflammatory pathways, thus worsening the illness. MicroRNAs (miRNAs) are tiny non-coding RNA molecules expressed within diverse tissues as well as cells and are engaged in different normal pathological and physiological pathways. Emerging proof suggests that miRNAs can impact innate and adaptive immunity, inflammatory responses, cell invasion, and the progression of viral infections. We discuss some intriguing new findings in the current work, focusing on the impacts of different miRNAs on host inflammatory responses and virus-mediated inflammation. A better understanding of dysregulated miRNAs in viral infections could improve the identification, prevention, and treatment of several serious diseases.

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微小核糖核酸在病毒介导的炎症中的调控作用。

人类的病毒感染通常会引起过度炎症。在某些病毒感染中，炎症可导致严重甚至致命的后果，而在另一些感染中，炎症则可促进病毒的清除。病毒可以通过调节炎症途径逃避宿主免疫系统的控制，从而使病情恶化。微小核糖核酸（miRNA）是在不同组织和细胞中表达的微小非编码核糖核酸分子，参与不同的正常病理和生理途径。新的证据表明，miRNA 可影响先天性和适应性免疫、炎症反应、细胞侵袭和病毒感染的进展。我们讨论了当前工作中一些引人入胜的新发现，重点是不同 miRNA 对宿主炎症反应和病毒介导的炎症的影响。更好地了解病毒感染中失调的 miRNA 可提高对多种严重疾病的识别、预防和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Inflammation-London IMMUNOLOGY-

CiteScore

7.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Inflammation welcomes research submissions on all aspects of inflammation. The five classical symptoms of inflammation, namely redness (rubor), swelling (tumour), heat (calor), pain (dolor) and loss of function (functio laesa), are only part of the story. The term inflammation is taken to include the full range of underlying cellular and molecular mechanisms involved, not only in the production of the inflammatory responses but, more importantly in clinical terms, in the healing process as well. Thus the journal covers molecular, cellular, animal and clinical studies, and related aspects of pharmacology, such as anti-inflammatory drug development, trials and therapeutic developments. It also considers publication of negative findings. Journal of Inflammation aims to become the leading online journal on inflammation and, as online journals replace printed ones over the next decade, the main open access inflammation journal. Open access guarantees a larger audience, and thus impact, than any restricted access equivalent, and increasingly so, as the escalating costs of printed journals puts them outside University budgets. The unrestricted access to research findings in inflammation aids in promoting dynamic and productive dialogue between industrial and academic members of the inflammation research community, which plays such an important part in the development of future generations of anti-inflammatory therapies.