Endometriosis, Anxiety, and Atherosclerosis: A Study of Eight Million Young Hospitalized Women in the USA.

IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Hormoz Nassiri Kigloo, Eva Suarthana, Tina Montreuil, Togas Tulandi
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引用次数: 0

Abstract

Objective: In recent years, several studies have proposed an association between endometriosis and various cardiovascular diseases. Our study evaluated the association between endometriosis and atherosclerosis in patients under 35 years of age using a large population database.

Design: This was a cross-sectional retrospective population-based study.

Participants/materials, setting, methods: We used the data of more than eight million hospitalized women under 35 years of age who were registered in one of the hospitals participating in the Healthcare Cost and Utilization Project - National Inpatient Sample (HCUP NIS) during the study period of 2007-2014. The prevalence of endometriosis, atherosclerosis, and related conditions was estimated, and logistic regression model was used to examine the association.

Results: In the period of study of 8,061,754 patients, we noted an upward pattern for the prevalence of atherosclerosis and a downward trend for endometriosis. Adjusting the analysis for sociodemographic characteristics and comorbidities, the probability of being diagnosed with atherosclerosis was 42% higher in patients with endometriosis (odds ratio [OR] = 1.421; 95% confidence interval [CI]: 1.058-1.910); 35% higher in patients with anxiety (OR = 1.352; 95% CI: 1.249-1.464); and three times higher in women with both endometriosis and anxiety (OR = 3.075; 95% CI: 1.969-4.803) compared to women without those conditions.

Limitations: In HCUP NIS databases, some information such as the severity of disease, laboratory findings, or medical treatment is not available.

Conclusion: The strong association between endometriosis and atherosclerosis suggests that they may share a similar mechanism possibly endothelial dysfunction related to chronic inflammation. Further studies on the potential role of psychological conditions, such as anxiety, on systemic inflammatory diseases are also deemed timely and important.

子宫内膜异位症、焦虑和动脉粥样硬化:对美国八百万年轻住院妇女的研究。
目的:近年来,一些研究提出了子宫内膜异位症与各种心血管疾病之间的关系。我们的研究利用大型人口数据库评估了 35 岁以下患者的子宫内膜异位症与动脉粥样硬化之间的关系:这是一项基于人群的回顾性研究:我们使用了2007年至2014年期间在参与医疗成本与利用项目--全国住院病人样本(HCUP NIS)的医院中登记的800多万名35岁以下住院妇女的数据。我们估算了子宫内膜异位症、动脉粥样硬化及相关疾病的患病率,并使用逻辑回归模型研究了两者之间的关联:结果:在研究期间,我们发现动脉粥样硬化的患病率呈上升趋势,而子宫内膜异位症的患病率呈下降趋势。在对社会人口学特征和合并症进行调整分析后,子宫内膜异位症患者被诊断为动脉粥样硬化的概率比没有这些疾病的女性高出42%(OR=1.421;95%CI 1.058-1.910);焦虑症患者高出35%(OR=1.352;95%CI 1.249-1.464);同时患有子宫内膜异位症和焦虑症的女性比没有这些疾病的女性高出3倍(OR=3.075;95%CI 1.969-4.803):局限性:HCUP NIS 数据库中没有提供疾病严重程度、实验室检查结果或治疗方法等信息:子宫内膜异位症与动脉粥样硬化之间的密切联系表明,它们可能具有类似的机制,即可能与慢性炎症有关的内皮功能障碍。关于焦虑等心理状况对全身性炎症性疾病的潜在作用的进一步研究也被认为是及时和重要的。
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来源期刊
CiteScore
4.20
自引率
4.80%
发文量
44
审稿时长
6-12 weeks
期刊介绍: This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.
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