Diabetes, IL-10 and the brain’s microvascular crisis

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-11-04 DOI:10.1038/s42255-024-01161-1

Celine E. Riera

引用次数: 0

Abstract

A new study finds that capillary vessels become obstructed in diabetes and that their dysfunction may cause microvascular damage and lead to cognitive deficits. Such obstruction is independent of the elevated blood sugar found in diabetes and is triggered by elevated interleukin-10 cytokine signalling in cerebral blood vessel endothelial cells.

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糖尿病、IL-10 和大脑微血管危机

一项新研究发现，糖尿病患者的毛细血管会发生阻塞，其功能障碍可能会造成微血管损伤，导致认知障碍。这种阻塞与糖尿病患者的血糖升高无关，是由脑血管内皮细胞中白细胞介素-10细胞因子信号的升高引发的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.