An overview of risk assessment and monitoring of malignant transformation in cirrhotic nodules.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-10-27 eCollection Date: 2024-01-01 DOI:10.1177/17562848241293019

Zhun Xiao, Fangming Yang, Zheng Liu, Xinju Chen, Suping Ma, Heng Li

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引用次数: 0

Abstract

Cirrhotic liver nodules can progress to hepatocellular carcinoma (HCC) through a multi-step carcinogenesis model, with dysplastic nodules being particularly high risk. Currently, monitoring the progression of non-HCC cirrhotic nodules is primarily through dynamic observation, but there is a lack of sensitive, efficient, and convenient methods. Dynamic monitoring and risk evaluation of malignant transformation are essential for timely treatment and improved patient survival rates. Routine liver biopsies are impractical for monitoring, and imaging techniques like ultrasound, computed tomography, and magnetic resonance imaging are not suitable for all patients or for accurately assessing subcentimeter nodules. Identifying serum biomarkers with high sensitivity, specificity, and stability, and developing a multi-index evaluation model, may provide a more convenient and efficient approach to monitoring pathological changes in cirrhotic nodules.

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肝硬化结节恶性转化的风险评估和监测概述。

肝硬化结节可通过多步骤癌变模式发展为肝细胞癌（HCC），其中发育不良结节的风险尤其高。目前，监测非 HCC 肝硬化结节进展的主要方法是动态观察，但缺乏灵敏、高效和便捷的方法。动态监测和恶性转化风险评估对于及时治疗和提高患者生存率至关重要。常规肝活检不适合监测，超声、计算机断层扫描和磁共振成像等成像技术也不适合所有患者或准确评估亚厘米结节。确定具有高敏感性、特异性和稳定性的血清生物标志物，并开发多指标评估模型，可为监测肝硬化结节的病理变化提供更方便、更有效的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567