Beyond acute infection: mechanisms underlying post-acute sequelae of COVID-19 (PASC)

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Medical Journal of Australia Pub Date : 2024-11-03 DOI:10.5694/mja2.52456

Anurag Adhikari, Janesha Maddumage, Emily M Eriksson, Sarah J Annesley, Victoria A Lawson, Vanessa L Bryant, Stephanie Gras

引用次数: 0

Abstract

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超越急性感染：COVID-19（PASC）急性后遗症的机制。

免疫失调是 2019 年冠状病毒病急性后遗症（PASC）（也称为长 COVID）的一个关键方面，免疫细胞持续激活、T 细胞衰竭、B 细胞特征偏差和免疫通讯紊乱从而导致与自身免疫相关的并发症。肠道正在成为微生物群、新陈代谢和整体功能障碍之间的关键环节，可能与其他慢性疲劳病症和 PASC 有相似之处。免疫血栓和神经信号系统功能障碍强调了在严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）感染的情况下，免疫系统、血液凝固和中枢神经系统之间复杂的相互作用。在设计 PASC 研究方面存在明显的研究空白，尤其是在纵向研究方面，这是一个值得关注的重要领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Journal of Australia 医学-医学：内科

CiteScore

9.40

自引率

5.30%

发文量

410

审稿时长

3-8 weeks

期刊介绍： The Medical Journal of Australia (MJA) stands as Australia's foremost general medical journal, leading the dissemination of high-quality research and commentary to shape health policy and influence medical practices within the country. Under the leadership of Professor Virginia Barbour, the expert editorial team at MJA is dedicated to providing authors with a constructive and collaborative peer-review and publication process. Established in 1914, the MJA has evolved into a modern journal that upholds its founding values, maintaining a commitment to supporting the medical profession by delivering high-quality and pertinent information essential to medical practice.