Cold Atmospheric Plasma: Possible Cure of Autoimmune Disorders and Cancer via Attenuating Inflammation.

IF 8.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
International Journal of Biological Sciences Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI:10.7150/ijbs.102445
Xiaofeng Dai, Shuo Feng, Yan Zheng
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引用次数: 0

Abstract

Autoimmune diseases and cancers, two seemingly unrelated diseases, have been threatening human health, and many of them have no cure. By identifying pathological inflammation as the driving cause of uncontrolled cell proliferation in both classes of diseases, and differentiating autoimmune disorders and cancers by whether the cell death programs are under control, we propose the attenuation of prolonged inflammation via maintaining mitochondrial reduction-oxidation (redox) homeostasis being a possible cure of both diseases. Importantly, we propose the feasibility of applying cold atmospheric plasma (CAP) in treating autoimmune disorders and cancers given its redox-modulatory nature, which not only extends the medical utilities of CAP to autoimmune diseases and all other inflammation-driven disorders, but also positions the efficacy of CAP against cancer cells to its suppressive role on prolonged inflammation. Our insights may open an innovative avenue towards a unified view on the molecular mechanism driving the diversified types of medical miracles of CAP and what CAP can do in the field of plasma medicine.

冷大气等离子体:通过减轻炎症可能治疗自身免疫性疾病和癌症
自身免疫性疾病和癌症这两种看似毫不相关的疾病一直威胁着人类的健康,其中许多疾病都无法治愈。通过确定病理炎症是这两类疾病中细胞增殖失控的驱动原因,并根据细胞死亡程序是否受到控制来区分自身免疫性疾病和癌症,我们提出了通过维持线粒体还原氧化(氧化还原)平衡来减轻长期炎症,从而治愈这两种疾病的可能性。重要的是,鉴于冷大气等离子体(CAP)的氧化还原调节特性,我们提出了应用冷大气等离子体治疗自身免疫性疾病和癌症的可行性,这不仅将冷大气等离子体的医疗用途扩展到了自身免疫性疾病和所有其他炎症驱动的疾病,而且还将冷大气等离子体对癌细胞的疗效定位为其对长期炎症的抑制作用。我们的洞察力可能会开辟一条创新之路,使人们对 CAP 创造各种医学奇迹的分子机制以及 CAP 在血浆医学领域的作用有一个统一的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Biological Sciences
International Journal of Biological Sciences 生物-生化与分子生物学
CiteScore
16.90
自引率
1.10%
发文量
413
审稿时长
1 months
期刊介绍: The International Journal of Biological Sciences is a peer-reviewed, open-access scientific journal published by Ivyspring International Publisher. It dedicates itself to publishing original articles, reviews, and short research communications across all domains of biological sciences.
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