Metabolic disorders, inter-organ crosstalk, and inflammation in the progression of metabolic dysfunction-associated steatotic liver disease

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2024-11-02 DOI:10.1016/j.lfs.2024.123211

Shendong Wang , Junhao Yin , Zhaojun Liu , Xin Liu , Ge Tian , Xijian Xin , Yiming Qin , Xiujing Feng

引用次数: 0

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a global health concern, affecting over 30 % of adults. It is a principal driver in the development of cirrhosis and hepatocellular carcinoma. The complex pathogenesis of MASLD involves an excessive accumulation of lipids, subsequently disrupting lipid metabolism and prompting inflammation within the liver. This review synthesizes the recent research progress in understanding the mechanisms contributing to MASLD progression, with particular emphasis on metabolic disorders and interorgan crosstalk. We highlight the molecular mechanisms linked to these factors and explore their potential as novel targets for pharmacological intervention. The insights gleaned from this article have important implications for both the prevention and therapeutic management of MASLD.

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代谢紊乱、器官间串联和炎症在代谢功能障碍相关性脂肪肝进展过程中的作用。

代谢功能障碍相关性脂肪性肝病（MASLD）是一个全球性的健康问题，影响着 30% 以上的成年人。它是导致肝硬化和肝细胞癌的主要因素。脂肪肝的发病机制复杂，包括脂质过度积累、脂质代谢紊乱和肝脏炎症。这篇综述综述了最近在了解导致 MASLD 进展的机制方面取得的研究进展，并特别强调了代谢紊乱和器官间串扰。我们强调了与这些因素相关的分子机制，并探讨了它们作为药物干预新靶点的潜力。本文的观点对预防和治疗 MASLD 都有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.