Cancer and treatment specific incidence rates of immune-related adverse events induced by immune checkpoint inhibitors: a systematic review.

IF 6.4 1区 医学 Q1 ONCOLOGY
Bishma Jayathilaka, Farah Mian, Fanny Franchini, George Au-Yeung, Maarten IJzerman
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引用次数: 0

Abstract

Background: Immune-related adverse events (irAE) induced by immune checkpoint inhibitors (ICI) are a treatment-limiting barrier. There are few large-scale studies that estimate irAE prevalence. This paper presents a systematic review that reports the prevalence of irAE by cancer type and ICI.

Methods: A systematic review was undertaken in MEDLINE OVID, EMBASE and Web of Science databases from 2017-2021. A total of 293 studies were identified for analysis and, of these, event rate was calculated for 272 studies, which involved 58,291 patients with irAE among 305,879 total patients on ICI. Event rate was calculated by irAE and ICI type.

Results: Mean event rate for general irAE occurrence across any grade was 40.0% (37.3-42.7%) and high grade was 19.7% (15.8-23.7%). Mean event rates for six specific types of irAE are reported. Mean event rate for ICI monotherapy was 29.7% (27.7-33.2%), 45.7% (29.6-61.7%) for ICI combination therapy, and 30.3% (27.3-35.0%) for both ICI monotherapy and combination therapy.

Conclusion: This systematic review characterises irAE prevalence across current research that examines irAE risk factors across cancers and ICI. The findings confirms that irAE occurrence is very common in the real-world setting, both high grade and irAE across any grade.

免疫检查点抑制剂诱发的免疫相关不良事件的癌症和治疗特异性发生率:系统综述。
背景:免疫检查点抑制剂(ICI)诱发的免疫相关不良事件(irAE)是限制治疗的障碍。目前很少有大规模研究估计irAE的发生率。本文介绍了一项系统性综述,按癌症类型和 ICI 报告了 irAE 的发生率:2017-2021年,在MEDLINE OVID、EMBASE和Web of Science数据库中进行了系统性综述。共确定了 293 项研究进行分析,并计算了其中 272 项研究的事件发生率,这些研究涉及 305879 名 ICI 患者中的 58291 名irAE 患者。事件发生率按虹膜急性缺损性和 ICI 类型进行计算:任何等级一般虹膜AE的平均事件发生率为40.0%(37.3-42.7%),高等级为19.7%(15.8-23.7%)。报告了六种特定类型虹膜睫状体异常的平均事件发生率。ICI单药治疗的平均事件发生率为29.7%(27.7-33.2%),ICI联合治疗的平均事件发生率为45.7%(29.6-61.7%),ICI单药治疗和联合治疗的平均事件发生率均为30.3%(27.3-35.0%):本系统性综述描述了当前研究中虹膜睫状体E发生率的特点,这些研究探讨了不同癌症和 ICI 的虹膜睫状体E风险因素。研究结果证实,虹膜睫状体异常在现实世界中非常常见,包括高级别虹膜睫状体异常和任何级别的虹膜睫状体异常。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
British Journal of Cancer
British Journal of Cancer 医学-肿瘤学
CiteScore
15.10
自引率
1.10%
发文量
383
审稿时长
6 months
期刊介绍: The British Journal of Cancer is one of the most-cited general cancer journals, publishing significant advances in translational and clinical cancer research.It also publishes high-quality reviews and thought-provoking comment on all aspects of cancer prevention,diagnosis and treatment.
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