Multiomic analysis of Lewisite exposed human dermal equivalent tissues

IF 4.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemico-Biological Interactions Pub Date : 2024-10-30 DOI:10.1016/j.cbi.2024.111295

Elizabeth S. Dhummakupt, Conor C. Jenkins, Gabrielle M. Rizzo, Allison E. Clay, Jennifer R. Horsmon, Tyler D.P. Goralski, Julie A. Renner, Daniel J. Angelini

引用次数: 0

Abstract

Lewisite (Military Code: L) is an arsenical vesicant chemical warfare agent (CWA) that was developed in the United States during World War I. Even though its use has not been documented in warfare, large stockpiles were created and still exist in various locations around the world. Given that large quantities exist as well as the relative straightforward process for its creation, Lewisite still presents itself as a serious threat agent. In this study, we examined the effects of Lewisite on human dermal equivalent tissues (EpiDerm™/EpiDerm™-FT) through the evaluation of cellular viability, histology, and multiomic analysis.

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对暴露于路易斯特的人体真皮等效组织进行多组学分析。

路易斯特（军用代号：L）是美国在第一次世界大战期间研制的一种砷类含泡化学战剂（CWA）。尽管没有战争使用路易斯特的记录，但美国还是制造了大量的路易斯特储存，至今仍存在于世界各地。鉴于其大量存在以及相对简单的制造过程，路易斯特仍然是一种严重的威胁物质。在本研究中，我们通过评估细胞活力、组织学和多组学分析，研究了路易斯特对人体真皮等效组织（EpiDerm™/EpiDerm™-FT）的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemico-Biological Interactions 生物-毒理学

CiteScore

7.70

自引率

3.90%

发文量

410

审稿时长

36 days

期刊介绍： Chemico-Biological Interactions publishes research reports and review articles that examine the molecular, cellular, and/or biochemical basis of toxicologically relevant outcomes. Special emphasis is placed on toxicological mechanisms associated with interactions between chemicals and biological systems. Outcomes may include all traditional endpoints caused by synthetic or naturally occurring chemicals, both in vivo and in vitro. Endpoints of interest include, but are not limited to carcinogenesis, mutagenesis, respiratory toxicology, neurotoxicology, reproductive and developmental toxicology, and immunotoxicology.