Long-Term Efficacy and Safety of Bimekizumab and Other Biologics in Moderate to Severe Plaque Psoriasis: Updated Systematic Literature Review and Network Meta-analysis.

IF 3.5 3区 医学 Q1 DERMATOLOGY
Richard B Warren, Kerry Donnelly, Sandeep Kiri, Vanessa Taieb, Mahmoud Slim, Kyle Fahrbach, Binod Neupane, Marissa Betts, April Armstrong
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引用次数: 0

Abstract

Introduction: Biologic treatments have made complete skin clearance in moderate to severe plaque psoriasis a real possibility. Although clinical trials demonstrated the superiority of bimekizumab over secukinumab, adalimumab, and ustekinumab, direct comparisons with other biologics are not available. This systematic literature review (SLR) and network meta-analysis (NMA) aimed to evaluate the 1-year efficacy and safety of bimekizumab versus other biologic systemic therapies for moderate to severe plaque psoriasis.

Methods: We conducted an SLR to retrieve published randomised controlled trials (RCTs) in patients with moderate to severe plaque psoriasis. We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews and PsycINFO on 13 January 2022. Two NMA types were used to analyse the long-term achievement of 100% improvement from baseline in Psoriasis Area and Severity Index (PASI 100): (1) NMA of cumulative clinical benefits, based on the area under the curve, from week 0 to 52; (2) multinomial NMA at weeks 44‒60. Binomial NMA was used to evaluate long-term serious adverse events (SAEs).

Results: The SLR identified 38 RCTs, of which 19 were included in the NMA. Bimekizumab 320 mg administered every 4 weeks to week 16 then every 8 weeks (Q4W/Q8W) showed a greater cumulative average number of days of PASI 100 response compared with all other biologics. These differences were statistically significant versus all biologics, except risankizumab 150 mg. The multinomial NMA demonstrated that interleukin (IL)-17 and IL-23 inhibitors were the most efficacious treatments. No significant differences were found in long-term occurrence of SAEs.

Conclusion: Bimekizumab 320 mg Q4W/Q8W was superior to most other treatments in maintaining complete skin clearance during the first year of treatment. It demonstrated a greater cumulative average number of days with completely clear skin while displaying a comparable safety profile compared with all other biologics.

比美单抗和其他生物制剂对中度至重度斑块状银屑病的长期疗效和安全性:最新系统文献综述和网络 Meta 分析。
简介:生物制剂治疗已使中度至重度斑块状银屑病患者的皮肤完全清除成为可能。尽管临床试验证明了bimekizumab优于secukinumab、adalimumab和ustekinumab,但尚无与其他生物制剂的直接比较。本系统性文献综述(SLR)和网络荟萃分析(NMA)旨在评估bimekizumab与其他生物制剂系统疗法治疗中重度斑块状银屑病的1年疗效和安全性:我们进行了一次SLR检索,以检索已发表的针对中重度斑块状银屑病患者的随机对照试验(RCT)。我们检索了2022年1月13日的MEDLINE、Embase、Cochrane对照试验中央登记册、Cochrane系统综述数据库和PsycINFO。采用两种NMA类型分析牛皮癣面积和严重程度指数(PASI 100)从基线改善100%的长期成就:(1)基于曲线下面积的累积临床获益NMA,从第0周到第52周;(2)第44-60周的多项式NMA。二项式 NMA 用于评估长期严重不良事件 (SAE):SLR确定了38项RCT,其中19项纳入了NMA。与所有其他生物制剂相比,比美单抗 320 毫克每 4 周给药一次至第 16 周,然后每 8 周给药一次(Q4W/Q8W),PASI 100 反应的累积平均天数更多。除利桑珠单抗 150 毫克外,与所有生物制剂相比,这些差异均具有统计学意义。多项式 NMA 显示,白细胞介素 (IL)-17 和 IL-23 抑制剂是最有效的治疗方法。在SAEs的长期发生率方面没有发现明显差异:结论:Bimekizumab 320 mg Q4W/Q8W 在治疗第一年保持皮肤完全清除方面优于大多数其他治疗方法。结论:与所有其他生物制剂相比,比美单抗 320 毫克 Q4W/Q8W 在保持皮肤完全清除方面优于大多数其他治疗方法,其皮肤完全清除的累积平均天数更多,同时显示出相当的安全性。
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来源期刊
Dermatology and Therapy
Dermatology and Therapy Medicine-Dermatology
CiteScore
6.00
自引率
8.80%
发文量
187
审稿时长
6 weeks
期刊介绍: Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.
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