Deciphering the roles of cellular and extracellular non-coding RNAs in chemotherapy-induced cardiotoxicity.

IF 3.5 2区 生物学 Q3 CELL BIOLOGY
Pan Feng, Fan Yang, Dongmei Zang, Dapeng Bai, Liyan Xu, Yueyun Fu, Ranran You, Tao Liu, Xinyu Yang
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引用次数: 0

Abstract

Chemotherapy-induced cardiotoxicity is a major adverse effect, driven by multiple factors in its pathogenesis. Notably, RNAs have emerged as significant contributors in both cancer and heart failure (HF). RNAs carry genetic and metabolic information that mirrors the current state of cells, making them valuable as potential biomarkers and therapeutic tools for diagnosing, predicting, and treating a range of diseases, including cardiotoxicity. Over 97% of the genome is transcribed into non-coding RNAs (ncRNAs), including ribosomal RNA (rRNAs), transfer RNAs (tRNAs), and newly identified microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs). NcRNAs function not only within their originating cells but also in recipient cells by being transported through extracellular compartments, referred to as extracellular RNAs (exRNAs). Since ncRNAs were identified as key regulators of gene expression, numerous studies have highlighted their significance in both cancer and cardiovascular diseases. Nevertheless, the role of ncRNAs in cardiotoxicity remains not fully elucidated. The study aims to review the existing knowledge on ncRNAs in Cardio-Oncology and explore the potential of ncRNA-based biomarkers and therapies. These investigations could advance the clinical application of ncRNA research, improving early detection and mitigating of chemotherapy-induced cardiotoxicity.

解密细胞和细胞外非编码 RNA 在化疗诱导的心脏毒性中的作用。
化疗诱发的心脏毒性是一种主要的不良反应,其发病机制由多种因素驱动。值得注意的是,RNA 已成为癌症和心力衰竭(HF)的重要致病因素。RNA 携带着反映细胞当前状态的遗传和代谢信息,使其成为诊断、预测和治疗包括心脏毒性在内的一系列疾病的潜在生物标记物和治疗工具。超过 97% 的基因组转录为非编码 RNA(ncRNA),包括核糖体 RNA(rRNA)、转移 RNA(tRNA)以及新发现的微 RNA(miRNA)、环状 RNA(circRNA)和长非编码 RNA(lncRNA)。NcRNA 不仅在其起源细胞内发挥作用,还通过胞外运输在受体细胞内发挥作用,被称为胞外 RNA(exRNA)。自从 ncRNA 被确定为基因表达的关键调控因子以来,许多研究都强调了它们在癌症和心血管疾病中的重要作用。然而,ncRNA 在心脏毒性中的作用仍未完全阐明。本研究旨在回顾有关 ncRNA 在心脑肿瘤学中的现有知识,并探索基于 ncRNA 的生物标记物和疗法的潜力。这些研究可推进 ncRNA 研究的临床应用,改善化疗引起的心脏毒性的早期检测和缓解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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