Novel Bragg peak characterization method using proton flux measurements on plastic scintillators.

IF 3.3 3区 医学 Q2 ENGINEERING, BIOMEDICAL
D R Guerreiro, J G Saraiva, L Peralta, C Rodrigues, M Rovituso, E van der Wal, Dennis R Schaart, P Crespo, H Simões, J M Sampaio
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引用次数: 0

Abstract

Objective. Bragg peak measurements play a key role in the beam quality assurance in proton therapy. Used as base data for the treatment planning softwares, the accuracy of the data is crucial when defining the range of the protons in the patient.Approach. In this paper a protocol to reconstruct a Pristine Bragg Peak exploring the direct correlation between the particle flux and the dose deposited by particles is presented. Proton flux measurements at the HollandPTC and FLUKA Monte Carlo simulations are used for this purpose. This new protocol is applicable to plastic scintillator detectors developed for Quality Assurance applications. In order to obtain the Bragg curve using a plastic fiber detector, a PMMA phantom with a decoupled and moveable stepper was designed. The step phantom allows to change the depth of material in front of the fiber detector during irradiations. The Pristine Bragg Peak reconstruction protocol uses the measured flux of particles at each position and multiplies it by the average dose obtained from the Monte Carlo simulation at each position.Main results. The results show that with this protocol it is possible to reconstruct the Bragg Peak with an accuracy of about 470µm, which is in accordance with the tolerances set by the AAPM.Significance. It has the advantage to be able to overcome the quenching problem of scintillators in the high ionization density region of the Bragg peak.

利用质子通量测量塑料闪烁体的新型布拉格峰表征方法。
\textit{Objective}.布拉格峰测量在质子治疗的射束质量保证中起着关键作用。作为治疗计划软件的基础数据,数据的准确性对于确定患者体内的质子范围、保护健康组织以及正确的容积剂量分布都至关重要。\方法本文介绍了重建原始布拉格峰的方案,以探索粒子通量与粒子沉积剂量之间的直接相关性。为此使用了在荷兰粒子物理中心(HollandPTC)进行的质子通量测量和 FLUKA 蒙特卡罗模拟。这一新方案适用于为质量保证应用而开发的塑料闪烁探测器。为了使用塑料光纤探测器获得布拉格曲线,设计了一个带有去耦合可移动步进装置的 PMMA 模型。阶梯模型允许在辐照过程中改变光纤探测器前的材料深度。原始布拉格峰重建协议使用在每个位置测得的粒子通量,并乘以在每个位置蒙特卡洛模拟得到的平均剂量。\文本{主要结果} 结果表明,使用该协议可以重建布拉格峰,精度约为 470 微米,符合 AAPM 规定的公差。此外,还讨论了协议的改进和进一步的应用。\意义它的优点是能够克服闪烁体在布拉格峰高电离密度区域的淬火问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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