Modulation of arachidonic acid metabolism in experimental arthritis induced by salmonella enteritidis I. Effect of ibuprofen and flurbiprofen on experimental arthritis induced by salmonella enteritidis

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-10-01 DOI:10.1016/0262-1746(87)90006-0

Rashida A. Karmali

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引用次数: 2

Abstract

Oral administration of two nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, can suppress the Salmonella-induced arthritis in rats. The joint swelling index of arthritic paws showed suppression of arthritis in animals treated with the drugs, this effect being greater with flurbiprofen. Measurement of 5 eicosanoids in femoral vein plasma showed increase of arachidonic acid products in Salmonella-treated rats. Inhibition of joint inflammation resulting from treatment with ibuprofen and flurbiprofen is reflected by a decrease in concentration of all 5 eicosanoids which were found in the order: PGE₂ > TXB₂ > 6-keto-PGF_1α > PGE₁ > PGF_2α. These studies indicate that flurbiprofen is a more powerful anti-inflammatory agent than ibuprofen. However, since the joint disease was not completely cured, optimal intervention is quite likely to require modulation of the lipoxygenase pathway.

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实验性肠炎沙门氏菌关节炎中花生四烯酸代谢的调节ⅰ。布洛芬和氟比洛芬对实验性肠炎沙门氏菌关节炎的影响

口服布洛芬和氟比洛芬两种非甾体抗炎药，可抑制大鼠沙门氏菌引起的关节炎。患关节炎的爪子的关节肿胀指数显示，用这些药物治疗的动物的关节炎得到抑制，氟比洛芬治疗的效果更大。对大鼠股静脉血浆中5种类二十烷酸的测定显示沙门氏菌处理后花生四烯酸产物增加。布洛芬和氟比洛芬治疗对关节炎症的抑制作用反映在所有5种类二十烷酸浓度的降低上，其顺序为:PGE2 >TXB2祝辞6-keto-PGF1α比;PGE1祝辞PGF2α。这些研究表明氟比洛芬是一种比布洛芬更有效的抗炎剂。然而，由于关节疾病尚未完全治愈，最佳干预很可能需要调节脂氧合酶途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prostaglandins, leukotrienes, and medicine

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