Targeting astrocytes polarization after spinal cord injury: a promising direction.

IF 4.2 3区 医学 Q2 NEUROSCIENCES
Frontiers in Cellular Neuroscience Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI:10.3389/fncel.2024.1478741
Helin Li, Ying Liu, Yucao Sun, Hangyu Guo, Shiyan Lv, Wenhui Guo, Jiyu Ren, Yufu Wang, Jianing Zu, Jinglong Yan, Nanxiang Wang
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引用次数: 0

Abstract

Spinal cord injury (SCI) is a serious neurological injury that causes severe trauma to motor and sensory functions. Although long considered incurable, recent research has brought new hope for functional recovery from SCI. After SCI, astrocytes are activated into many polarization states. Here we discuss the two most important classical phenotypes: the 'A1' neurotoxic phenotype and the 'A2' neuroprotective phenotype, with A1 astrocytes being neurotoxic and impeding neurorecovery, and A2 astrocytes being neuroprotective. This paper discusses the changes in astrocyte responsiveness after SCI and the pros and cons of their polarization in SCI. It also elucidates the feasibility of astrocyte polarization as a therapeutic target for neuroprotection. In the future, multiple intervention strategies targeting astrocyte polarization are expected to gain wider clinical application, ultimately improving motor-sensory function and quality of life in SCI patients.

针对脊髓损伤后的星形胶质细胞极化:一个前景光明的方向。
脊髓损伤(SCI)是一种严重的神经损伤,会对运动和感觉功能造成严重创伤。虽然长期以来被认为是不治之症,但最近的研究为 SCI 的功能恢复带来了新的希望。SCI 后,星形胶质细胞被激活,进入多种极化状态。我们在此讨论两种最重要的经典表型:"A1 "神经毒性表型和 "A2 "神经保护性表型,其中 A1 星形胶质细胞具有神经毒性并阻碍神经恢复,而 A2 星形胶质细胞具有神经保护性。本文讨论了损伤后星形胶质细胞反应性的变化及其在损伤中极化的利弊。本文还阐明了星形胶质细胞极化作为神经保护治疗靶点的可行性。未来,针对星形胶质细胞极化的多种干预策略有望获得更广泛的临床应用,最终改善 SCI 患者的运动感觉功能和生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.90
自引率
3.80%
发文量
627
审稿时长
6-12 weeks
期刊介绍: Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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