Uncommon granulomatous manifestation in Epstein-Barr virus-positive follicular dendritic cell sarcoma: a case report.

IF 1.7 Q3 PATHOLOGY
Henry Goh Di Shen, Yue Zhang, Wei Qiang Leow
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引用次数: 0

Abstract

Hepatic Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS) represents a rare form of liver malignancy. The absence of distinct clinical and radiological characteristics, compounded by its rare occurrence, contributes to a challenging diagnosis. Here, we report a case of a 54-year-old Chinese female with a background of chronic hepatitis B virus treated with entecavir and complicated by advanced fibrosis presenting with a liver mass found on her annual surveillance ultrasound. Hepatectomy was performed under clinical suspicion of hepatocellular carcinoma. Immunomorphologic characteristics of the tumor were consistent with EBV+ IFDCS with distinct non-caseating granulomatous inflammation. Our case illustrates the importance of considering EBV+ IFDCS in the differential diagnosis of hepatic inflammatory lesions. Awareness of this entity and its characteristic features is essential for accurately diagnosing and managing this rare neoplasm.

爱泼斯坦-巴氏病毒阳性滤泡树突状细胞肉瘤的罕见肉芽肿表现:病例报告。
肝脏爱泼斯坦-巴氏病毒阳性炎性滤泡树突状细胞肉瘤(EBV+ IFDCS)是一种罕见的肝脏恶性肿瘤。由于缺乏明显的临床和放射学特征,加之其罕见的发生率,导致其诊断极具挑战性。在此,我们报告了一例 54 岁的中国女性病例,她患有慢性乙型肝炎病毒,曾接受恩替卡韦治疗,并并发晚期肝纤维化,在年度监测超声检查中发现肝脏肿块。在临床怀疑为肝细胞癌的情况下进行了肝切除术。肿瘤的免疫形态学特征与 EBV+ IFDCS 一致,并伴有明显的非酪氨酸肉芽肿性炎症。我们的病例说明了在肝脏炎症病变的鉴别诊断中考虑 EBV+ IFDCS 的重要性。了解这种肿瘤及其特征对于准确诊断和处理这种罕见肿瘤至关重要。
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来源期刊
CiteScore
5.00
自引率
4.20%
发文量
45
审稿时长
14 weeks
期刊介绍: The Journal of Pathology and Translational Medicine is an open venue for the rapid publication of major achievements in various fields of pathology, cytopathology, and biomedical and translational research. The Journal aims to share new insights into the molecular and cellular mechanisms of human diseases and to report major advances in both experimental and clinical medicine, with a particular emphasis on translational research. The investigations of human cells and tissues using high-dimensional biology techniques such as genomics and proteomics will be given a high priority. Articles on stem cell biology are also welcome. The categories of manuscript include original articles, review and perspective articles, case studies, brief case reports, and letters to the editor.
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