Mechano-assisted strategies to improve cancer chemotherapy

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2024-10-28 DOI:10.1016/j.lfs.2024.123178

Shanshan Zhu , Guorui Jin , Xiaocong He , Yuan Li , Feng Xu , Hui Guo

引用次数: 0

Abstract

Chemotherapy remains a cornerstone in cancer treatment; however, its effectiveness is frequently undermined by the development of drug resistance. Recent studies underscores the pivotal role of the tumor mechanical microenvironment (TMME) and the emerging field of mechanical nanomedicine in tackling chemo-resistance. This review offers an in-depth analysis of mechano-assisted strategies aimed at mitigating chemo-resistance through the modification of the TMME and the refinement of mechanical nanomedicine delivery systems. We explore the potential of targeting abnormal tumor mechanical properties as a promising avenue for enhancing the efficacy of cancer chemotherapy, which offers novel directions for advancing future cancer therapies, especially from the mechanomedicine perspective.

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改善癌症化疗的机械辅助策略。

化疗仍然是癌症治疗的基石，但其有效性经常因耐药性的产生而受到影响。最近的研究强调了肿瘤机械微环境（TMME）和新兴的机械纳米医学领域在解决化疗耐药性方面的关键作用。本综述深入分析了旨在通过改变肿瘤机械微环境和改进机械纳米药物输送系统来减轻化疗耐药性的机械辅助策略。我们探讨了以异常肿瘤机械特性为靶点作为提高癌症化疗疗效的潜在途径，这为推进未来的癌症疗法提供了新的方向，尤其是从机械医学的角度来看。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.