Peroxisome inter-organelle cooperation in Drosophila.

IF 2.3 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Genome Pub Date : 2024-10-29 DOI:10.1139/gen-2024-0082
Andy Y Cheng, Andrew J Simmonds
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引用次数: 0

Abstract

Many cellular functions are compartmentalized within the optimized environments of organelles. However, processing or storage of metabolites from the same pathway can occur in multiple organelles. Thus, spatially separated organelles need to cooperate functionally. Coordination between organelles in different specialized cells is also needed, with shared metabolites passed via circulation. Peroxisomes are membrane-bounded organelles responsible for cellular redox and lipid metabolism in eukaryotic cells. Peroxisomes coordinate with other organelles including mitochondria, endoplasmic reticulum, lysosomes, and lipid droplets. This functional coordination requires, or is at least enhanced by, direct contact between peroxisomes and other organelles. Peroxisome dysfunction in humans leads to multiorgan effects including neurological, metabolic, developmental, and age-related diseases. Thus, increased understanding of peroxisome coordination with other organelles, especially cells in various organs is essential. Drosophila melanogaster (fruit fly) has emerged recently as an effective animal model for understanding peroxisomes. Here we review current knowledge of pathways regulating coordination between peroxisomes with other organelles in flies, speculating about analogous roles for conserved Drosophila genes encoding proteins with known organelle coordinating roles in other species.

果蝇的过氧物酶体细胞器间合作
在许多细胞器内,生化功能被分隔开来,这有利于优化酶环境。然而,同一途径中代谢物的加工和储存可在多个细胞器中进行。因此,空间上分离的细胞器需要在功能上进行合作。不同特化细胞中的细胞器之间也需要协调,通过循环传递共享的代谢物。过氧物酶体是真核细胞中负责细胞氧化还原和脂质代谢的膜束细胞器。利用单细胞进行的研究表明,过氧物酶体与线粒体、ER(内质网)、溶酶体和脂滴等其他细胞器相互协调。其中一些协调功能需要过氧物酶体与其他细胞器直接接触,或至少通过这种接触得到加强。人体过氧化物酶体功能障碍会导致多器官的影响,包括神经、代谢、发育和与年龄有关的疾病。因此,进一步了解过氧物酶体与其他细胞器(尤其是各器官中的特化细胞)之间的协调至关重要。黑腹果蝇(果蝇)近来已成为了解过氧物酶体的有效动物模型。在这里,我们回顾了目前关于调控果蝇过氧物酶体与其他细胞器协调的遗传途径的知识,并推测了果蝇保守基因在其他物种中编码已知具有细胞器协调作用的蛋白质的类似作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Genome
Genome 生物-生物工程与应用微生物
CiteScore
5.30
自引率
3.20%
发文量
42
审稿时长
6-12 weeks
期刊介绍: Genome is a monthly journal, established in 1959, that publishes original research articles, reviews, mini-reviews, current opinions, and commentaries. Areas of interest include general genetics and genomics, cytogenetics, molecular and evolutionary genetics, developmental genetics, population genetics, phylogenomics, molecular identification, as well as emerging areas such as ecological, comparative, and functional genomics.
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