Exploring the underlying mechanisms of exercise as therapy for multiple sclerosis: insights from preclinical studies.

IF 4.2 3区医学 Q2 NEUROSCIENCES

Frontiers in Cellular Neuroscience Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI:10.3389/fncel.2024.1460262

Yunpeng Du, Shuhan Dong, Wei Zou

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引用次数: 0

Abstract

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system CNS characterized by demyelination, inflammation, and neurodegenerative changes, making it the most common nontraumatic disabling neurological disease in young adults. While current pharmacological treatments primarily target immunomodulation or immunosuppression, exercise is gaining increasing attention from the scientific community as an adjunctive therapy. This review explores the potential biological mechanisms of exercise in animal models of MS, focusing on its effects on neuroprotection and inflammation. The review examines how exercise inhibits pro-inflammatory microglial reactivity, stabilizes the blood-brain barrier, and enhances neurotrophic factor expression in animal studies. Future research directions are proposed by summarizing the evidence and limitations of existing animal models of MS, emphasizing the need to further validate these mechanisms in humans to better integrate exercise into the comprehensive management of MS. Additionally, investigating exercise-induced biomarkers for MS symptom reduction may provide a scientific basis for new therapeutic strategies.

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探索运动治疗多发性硬化症的内在机制：临床前研究的启示。

多发性硬化症（MS）是一种免疫介导的中枢神经系统疾病，以脱髓鞘、炎症和神经退行性病变为特征，是青壮年中最常见的非创伤性致残神经系统疾病。虽然目前的药物治疗主要针对免疫调节或免疫抑制，但运动作为一种辅助疗法正日益受到科学界的关注。本综述探讨了运动在多发性硬化症动物模型中的潜在生物学机制，重点关注其对神经保护和炎症的影响。综述探讨了运动如何在动物实验中抑制促炎性小胶质细胞反应、稳定血脑屏障并增强神经营养因子的表达。通过总结现有多发性硬化症动物模型的证据和局限性，提出了未来的研究方向，强调需要在人体中进一步验证这些机制，以便更好地将运动纳入多发性硬化症的综合治疗中。此外，研究运动诱导的减轻多发性硬化症症状的生物标志物可为新的治疗策略提供科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cellular Neuroscience NEUROSCIENCES-

CiteScore

7.90

自引率

3.80%

发文量

627

审稿时长

6-12 weeks

期刊介绍： Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.