Effects of anodal transcranial direct current stimulation on intracranial compliance in the subacute phase of stroke

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
{"title":"Effects of anodal transcranial direct current stimulation on intracranial compliance in the subacute phase of stroke","authors":"","doi":"10.1016/j.clineuro.2024.108597","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Transcranial direct current stimulation (tDCS) increases cerebral blood flow. This study evaluated the effects of anodal tDCS (A-tDCS) on intracranial compliance (ICC) in patients with subacute stroke using a non-invasive method.</div></div><div><h3>Methods</h3><div>This was a randomized, proof-of-concept, double-blind, pilot study. Patients with ischemic stroke of the middle cerebral artery (MCA) were divided into the following two groups: 1) A-tDCS in the motor cortex on the affected side for 30 min at 2 mA, and 2) sham tDCS in the motor cortex on the affected side. The primary outcomes were intracranial compliance (P2/P1 ratio and time-to-peak [TTP]) and ICC normalization after the intervention (P2/P1 ratio &lt;1). Secondary outcomes were systolic and diastolic blood pressures, heart rate, and peripheral oxygen saturation.</div></div><div><h3>Results</h3><div>No significant differences were observed in the P2/P1 ratio (P = 0.509) and TTP (P = 0.480) between the groups. However, the A-tDCS group was significantly associated with a normal P2/P1 ratio after intervention (B = 2.583; standard error [SE]: 1.277; P = 0.043; corrected for age and stroke severity). No significant associations were observed between the groups and systolic blood pressure (F = 0.16; P = 0.902), diastolic blood pressure (F = 0.18; P = 0.892), heart rate (F = 0.11; P = 0.950), or peripheral oxygen saturation (F = 0.21; P = 0.750).</div></div><div><h3>Conclusion</h3><div>ICC morphology normalization was observed in the A-tDCS group. However, no differences were observed in the P2/P1 ratio, TTP, or hemodynamic variables between the groups. A sample size of 66 patients with ischemic stroke of the MCA can be estimated using the observed effect size and standard α = 5 % and β = 20 % for future trials. Furthermore, this will aid in conducting the necessary randomized trials targeting these populations.</div></div>","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurology and Neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0303846724004840","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives

Transcranial direct current stimulation (tDCS) increases cerebral blood flow. This study evaluated the effects of anodal tDCS (A-tDCS) on intracranial compliance (ICC) in patients with subacute stroke using a non-invasive method.

Methods

This was a randomized, proof-of-concept, double-blind, pilot study. Patients with ischemic stroke of the middle cerebral artery (MCA) were divided into the following two groups: 1) A-tDCS in the motor cortex on the affected side for 30 min at 2 mA, and 2) sham tDCS in the motor cortex on the affected side. The primary outcomes were intracranial compliance (P2/P1 ratio and time-to-peak [TTP]) and ICC normalization after the intervention (P2/P1 ratio <1). Secondary outcomes were systolic and diastolic blood pressures, heart rate, and peripheral oxygen saturation.

Results

No significant differences were observed in the P2/P1 ratio (P = 0.509) and TTP (P = 0.480) between the groups. However, the A-tDCS group was significantly associated with a normal P2/P1 ratio after intervention (B = 2.583; standard error [SE]: 1.277; P = 0.043; corrected for age and stroke severity). No significant associations were observed between the groups and systolic blood pressure (F = 0.16; P = 0.902), diastolic blood pressure (F = 0.18; P = 0.892), heart rate (F = 0.11; P = 0.950), or peripheral oxygen saturation (F = 0.21; P = 0.750).

Conclusion

ICC morphology normalization was observed in the A-tDCS group. However, no differences were observed in the P2/P1 ratio, TTP, or hemodynamic variables between the groups. A sample size of 66 patients with ischemic stroke of the MCA can be estimated using the observed effect size and standard α = 5 % and β = 20 % for future trials. Furthermore, this will aid in conducting the necessary randomized trials targeting these populations.
阳极经颅直流电刺激对中风亚急性期颅内顺应性的影响。
目标:经颅直流电刺激(tDCS经颅直流电刺激(tDCS)可增加脑血流量。本研究采用无创方法评估了阳极 tDCS(A-tDCS)对亚急性中风患者颅内顺应性(ICC)的影响:这是一项随机、概念验证、双盲、试验性研究。大脑中动脉(MCA)缺血性中风患者被分为以下两组:1)在患侧运动皮层进行 30 分钟、2 毫安的 A-tDCS 治疗;2)在患侧运动皮层进行假 tDCS 治疗。主要结果是颅内顺应性(P2/P1 比值和峰值时间 [TTP])和干预后 ICC 正常化(P2/P1 比值 结果):两组间的 P2/P1 比值(P = 0.509)和 TTP(P = 0.480)无明显差异。然而,A-tDCS 组与干预后正常的 P2/P1 比值有明显相关性(B = 2.583;标准误差 [SE]:1.277; P = 0.043;根据年龄和中风严重程度校正)。各组间未观察到收缩压(F = 0.16;P = 0.902)、舒张压(F = 0.18;P = 0.892)、心率(F = 0.11;P = 0.950)或外周血氧饱和度(F = 0.21;P = 0.750)的明显关联:结论:A-tDCS 组观察到 ICC 形态正常化。结论:A-tDCS 组观察到 ICC 形态正常化,但两组间的 P2/P1 比值、TTP 或血液动力学变量未见差异。根据观察到的效应大小和标准 α = 5 % 和 β = 20 %,可估算出 66 名 MCA 缺血性中风患者的样本量,供未来试验使用。此外,这将有助于针对这些人群开展必要的随机试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Clinical Neurology and Neurosurgery
Clinical Neurology and Neurosurgery 医学-临床神经学
CiteScore
3.70
自引率
5.30%
发文量
358
审稿时长
46 days
期刊介绍: Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信