Lipids associated with autophagy: mechanisms and therapeutic targets.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2024-10-30 DOI:10.1038/s41420-024-02224-8

Michał Jarocki, Kacper Turek, Jolanta Saczko, Mounir Tarek, Julita Kulbacka

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Abstract

Autophagy is a molecular process essential for maintaining cellular homeostasis, with its impairment or dysregulation linked to the progression of various diseases in mammals. Specific lipids, including phosphoinositides, sphingolipids, and oxysterols, play pivotal roles in inducing and regulating autophagy, highlighting their significance in this intricate process. This review focuses on the critical involvement of these lipids in autophagy and lipophagy, providing a comprehensive overview of the current understanding of their functions. Moreover, we delve into how abnormalities in autophagy, influenced by these lipids, contribute to the pathogenesis of various diseases. These include age-related conditions such as cardiovascular diseases, neurodegenerative disorders, type 2 diabetes, and certain cancers, as well as inflammatory and liver diseases, skeletal muscle pathologies and age-related macular degeneration (AMD). This review aims to highlight function of lipids and their potential as therapeutic targets in treating diverse human pathologies by elucidating the specific roles of phosphoinositides, sphingolipids, and oxysterols in autophagy.

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与自噬有关的脂质：机制和治疗目标。

自噬是维持细胞稳态必不可少的分子过程，其损伤或失调与哺乳动物各种疾病的进展有关。特定的脂质，包括磷脂、鞘脂和氧基固醇，在诱导和调节自噬过程中发挥着关键作用，凸显了它们在这一复杂过程中的重要意义。本综述重点探讨了这些脂质在自噬和噬脂中的关键作用，全面概述了目前对其功能的理解。此外，我们还深入探讨了受这些脂质影响的自噬异常是如何导致各种疾病发病的。这些疾病包括与年龄有关的疾病，如心血管疾病、神经退行性疾病、2 型糖尿病和某些癌症，以及炎症和肝脏疾病、骨骼肌病变和老年性黄斑变性（AMD）。本综述旨在通过阐明磷脂、鞘磷脂和氧杂环醇在自噬中的特定作用，强调脂质的功能及其作为治疗靶点治疗各种人类病症的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.