RNA modification regulators as promising biomarkers in gynecological cancers.

IF 5.3 2区医学 Q2 CELL BIOLOGY

Cell Biology and Toxicology Pub Date : 2024-10-29 DOI:10.1007/s10565-024-09924-y

Yue Qi, Tian Li, Yang Zhou, Yingying Hao, Jin Zhang

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引用次数: 0

Abstract

This review explores the evolving landscape of gynecological oncology by focusing on emerging RNA modification signatures as promising biomarkers for assessing the risk and progression of ovarian, cervical, and uterine cancers. It provides a comprehensive overview of common RNA modifications, especially m6A, and their roles in cellular processes, emphasizing their implications in gynecological cancer development. The review meticulously examines specific m6A regulators including "writers", "readers", and "erasers" associated with three gynecological cancer types, discussing their involvement in initiation and progression. Methodologies for detecting RNA modifications are surveyed, highlighting advancements in high-throughput techniques with high sensitivity. A critical analysis of studies identifying m6A regulators as potential biomarkers is presented, addressing their diagnostic or prognostic significance. Mechanistic insights into RNA modification-mediated cancer progression are explored, shedding light on molecular pathways and potential therapeutic targets. Despite current challenges, the review discusses ongoing research efforts, future directions, and the transformative possibility of RNA modifications on early assessment and personalized therapy in gynecological oncology.

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作为妇科癌症生物标志物的 RNA 修饰调节因子大有可为。

这篇综述探讨了妇科肿瘤学不断发展的前景，重点研究了作为评估卵巢癌、宫颈癌和子宫癌风险和进展的有前途生物标记物的新兴 RNA 修饰特征。它全面概述了常见的 RNA 修饰（尤其是 m6A）及其在细胞过程中的作用，强调了它们在妇科癌症发展中的意义。该综述细致研究了与三种妇科癌症类型相关的特定 m6A 调节因子，包括 "书写者"、"阅读者 "和 "擦除者"，讨论了它们在癌症发生和发展过程中的参与。文章对检测 RNA 修饰的方法进行了调查，重点介绍了高通量、高灵敏度技术的进展。报告对确定 m6A 调节因子为潜在生物标记物的研究进行了批判性分析，探讨了它们在诊断或预后方面的意义。综述探讨了 RNA 修饰介导的癌症进展机制，揭示了分子途径和潜在的治疗靶点。尽管目前存在挑战，但综述讨论了正在进行的研究工作、未来方向以及 RNA 修饰在妇科肿瘤学早期评估和个性化治疗方面的变革可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biology and Toxicology 生物-毒理学

CiteScore

9.90

自引率

4.90%

发文量

101

审稿时长

>12 weeks

期刊介绍： Cell Biology and Toxicology (CBT) is an international journal focused on clinical and translational research with an emphasis on molecular and cell biology, genetic and epigenetic heterogeneity, drug discovery and development, and molecular pharmacology and toxicology. CBT has a disease-specific scope prioritizing publications on gene and protein-based regulation, intracellular signaling pathway dysfunction, cell type-specific function, and systems in biomedicine in drug discovery and development. CBT publishes original articles with outstanding, innovative and significant findings, important reviews on recent research advances and issues of high current interest, opinion articles of leading edge science, and rapid communication or reports, on molecular mechanisms and therapies in diseases.