Thermal and sublimation properties of cardiovascular drugs sotalol and ivabradine hydrochlorides

IF 2.2 3区工程技术 Q3 CHEMISTRY, PHYSICAL

Journal of Chemical Thermodynamics Pub Date : 2024-10-16 DOI:10.1016/j.jct.2024.107400

Svetlana Blokhina, Marina Ol’khovich, Angelica Sharapova

引用次数: 0

Abstract

The saturated vapor pressure of sotalol and ivabradine hydrochlorides was measured in the temperature range (413.15–437.15) K by the transpiration method. The sublimation thermodynamic functions (Gibbs energy, enthalpy and entropy) of the compounds were calculated from the temperature dependencies of saturated vapor pressure. The standard molar enthalpy of sublimation for sotalol and ivabradine hydrochlorides is (157.5 ± 1.4) kJ·mol⁻¹ and (143.2 ± 1.2) kJ·mol⁻¹, respectively. The thermal properties and crystal state of the drugs were studied by the DSC, TG/DTG and X-ray diffraction methods.

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心血管药物索他洛尔和伊伐布雷定盐酸盐的热和升华特性

采用蒸腾法测量了索他洛尔和盐酸伊伐布雷定在温度范围（413.15-437.15）K 下的饱和蒸气压。根据饱和蒸气压的温度相关性计算出了化合物的升华热力学函数（吉布斯能、焓和熵）。索他洛尔和伊伐布雷定盐酸盐的标准摩尔升华焓分别为 (157.5 ± 1.4) kJ-mol-1 和 (143.2 ± 1.2) kJ-mol-1。通过 DSC、TG/DTG 和 X 射线衍射方法研究了药物的热性质和晶体状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chemical Thermodynamics 工程技术-热力学

CiteScore

5.60

自引率

15.40%

发文量

199

审稿时长

79 days

期刊介绍： The Journal of Chemical Thermodynamics exists primarily for dissemination of significant new knowledge in experimental equilibrium thermodynamics and transport properties of chemical systems. The defining attributes of The Journal are the quality and relevance of the papers published. The Journal publishes work relating to gases, liquids, solids, polymers, mixtures, solutions and interfaces. Studies on systems with variability, such as biological or bio-based materials, gas hydrates, among others, will also be considered provided these are well characterized and reproducible where possible. Experimental methods should be described in sufficient detail to allow critical assessment of the accuracy claimed. Authors are encouraged to provide physical or chemical interpretations of the results. Articles can contain modelling sections providing representations of data or molecular insights into the properties or transformations studied. Theoretical papers on chemical thermodynamics using molecular theory or modelling are also considered. The Journal welcomes review articles in the field of chemical thermodynamics but prospective authors should first consult one of the Editors concerning the suitability of the proposed review. Contributions of a routine nature or reporting on uncharacterised materials are not accepted.