Fabrication and in vitro biological properties of hydroxyapatite-sodium potassium niobate-barium titanate piezoelectric bioceramics

IF 4.3 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Majid Kaboosi , Leila Nikzad , Iman Mobasherpour , S. Amir Ghaffari
{"title":"Fabrication and in vitro biological properties of hydroxyapatite-sodium potassium niobate-barium titanate piezoelectric bioceramics","authors":"Majid Kaboosi ,&nbsp;Leila Nikzad ,&nbsp;Iman Mobasherpour ,&nbsp;S. Amir Ghaffari","doi":"10.1016/j.matchemphys.2024.130060","DOIUrl":null,"url":null,"abstract":"<div><div>The utilization of piezoelectric materials in bone implants is appealing due to the inherent piezoelectric property of natural bone. The intrinsic electrical characteristics of piezoelectric biomaterials enhance antibacterial activities, biocompatibility, and bioactivity properties. This study delves into investigating the antibacterial properties, biocompatibility, and bioactivity of three-component biocomposites: sodium potassium niobate (KNN)-barium titanate (BT)-hydroxyapatite (HA). The combination of sodium potassium niobate and barium titanate, possessing suitable piezoelectric properties, with hydroxyapatite, known for its favorable biological properties, enhances the requisite properties for a bone implant. Among the various compositions studied, the combination comprising 70 wt% of the piezoelectric component (KNN-BT) and 30 wt% hydroxyapatite, labeled as 30HKB, emerged as the most optimal blend in terms of density, morphotropic phase boundary, and other biological tests conducted. Following polarization, the antibacterial efficacy of 30HKB against S. aureus bacteria cells increased by 61 %. Furthermore, the growth and adhesion of MC3T3-E1 osteoblast cells suggest enhanced biocompatibility of the 30HKB composite attributed to surface polarization. The surface charges generated by polarization facilitated the absorption of Ca2+ ions, as well as the interaction of HPO4 - and OH- ions with the precipitated Ca2+ ions, leading to the formation of the CaP layer. Hence, polarized piezoelectric ceramics exhibit heightened bioactivity compared to their non-polarized counterparts.</div></div>","PeriodicalId":18227,"journal":{"name":"Materials Chemistry and Physics","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Chemistry and Physics","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S025405842401188X","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

The utilization of piezoelectric materials in bone implants is appealing due to the inherent piezoelectric property of natural bone. The intrinsic electrical characteristics of piezoelectric biomaterials enhance antibacterial activities, biocompatibility, and bioactivity properties. This study delves into investigating the antibacterial properties, biocompatibility, and bioactivity of three-component biocomposites: sodium potassium niobate (KNN)-barium titanate (BT)-hydroxyapatite (HA). The combination of sodium potassium niobate and barium titanate, possessing suitable piezoelectric properties, with hydroxyapatite, known for its favorable biological properties, enhances the requisite properties for a bone implant. Among the various compositions studied, the combination comprising 70 wt% of the piezoelectric component (KNN-BT) and 30 wt% hydroxyapatite, labeled as 30HKB, emerged as the most optimal blend in terms of density, morphotropic phase boundary, and other biological tests conducted. Following polarization, the antibacterial efficacy of 30HKB against S. aureus bacteria cells increased by 61 %. Furthermore, the growth and adhesion of MC3T3-E1 osteoblast cells suggest enhanced biocompatibility of the 30HKB composite attributed to surface polarization. The surface charges generated by polarization facilitated the absorption of Ca2+ ions, as well as the interaction of HPO4 - and OH- ions with the precipitated Ca2+ ions, leading to the formation of the CaP layer. Hence, polarized piezoelectric ceramics exhibit heightened bioactivity compared to their non-polarized counterparts.
羟基磷灰石-铌酸钠钾-钛酸钡压电生物陶瓷的制作和体外生物特性
由于天然骨骼具有固有的压电特性,在骨植入物中使用压电材料很有吸引力。压电生物材料固有的电特性可提高抗菌活性、生物相容性和生物活性。本研究深入探讨了铌酸钾钠(KNN)-钛酸钡(BT)-羟基磷灰石(HA)三组分生物复合材料的抗菌特性、生物相容性和生物活性。铌酸钾钠和钛酸钡具有适当的压电特性,而羟基磷灰石具有良好的生物特性,两者的结合增强了骨植入物的必要特性。在所研究的各种成分中,压电成分(KNN-BT)占 70%,羟基磷灰石占 30%(标记为 30HKB),就密度、各向异性相界和其他生物测试而言,这种组合是最理想的混合物。极化后,30HKB 对金黄色葡萄球菌细胞的抗菌效力提高了 61%。此外,MC3T3-E1 成骨细胞的生长和粘附表明,30HKB 复合材料的生物相容性因表面极化而得到增强。极化产生的表面电荷促进了 Ca2+ 离子的吸收,以及 HPO4 - 和 OH- 离子与沉淀的 Ca2+ 离子的相互作用,导致 CaP 层的形成。因此,与非极化陶瓷相比,极化压电陶瓷具有更高的生物活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Materials Chemistry and Physics
Materials Chemistry and Physics 工程技术-材料科学:综合
CiteScore
8.70
自引率
4.30%
发文量
1515
审稿时长
69 days
期刊介绍: Materials Chemistry and Physics is devoted to short communications, full-length research papers and feature articles on interrelationships among structure, properties, processing and performance of materials. The Editors welcome manuscripts on thin films, surface and interface science, materials degradation and reliability, metallurgy, semiconductors and optoelectronic materials, fine ceramics, magnetics, superconductors, specialty polymers, nano-materials and composite materials.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信