Hydroxyapatite–polymer nanocomposites for drug delivery applications: A mini review

European Journal of Medicinal Chemistry Reports Pub Date : 2024-10-18 DOI:10.1016/j.ejmcr.2024.100231

Farnaz Behmagham , Shahad Mohammed Dhiaa , Abbas Hameed Abdul Hussein , Usama Kadem Radi , Hiba Mushtaq , Ameer Hassan Idan , Esmail Vessally

{"title":"Hydroxyapatite–polymer nanocomposites for drug delivery applications: A mini review","authors":"Farnaz Behmagham , Shahad Mohammed Dhiaa , Abbas Hameed Abdul Hussein , Usama Kadem Radi , Hiba Mushtaq , Ameer Hassan Idan , Esmail Vessally","doi":"10.1016/j.ejmcr.2024.100231","DOIUrl":null,"url":null,"abstract":"<div><div>Prescribing drugs in a traditional way causes drug resistance and side effects. New strategies are being developed to solve these problems and to deliver drugs safely and efficiently to damaged tissues. Drug delivery systems are one of the successful strategies for delivering drugs to the disease site in the body. Hydroxyapatite (HA) due to its similarity to the compositional of bone and tooth and biocompatibility has received more attention in biomedical applications. Nonetheless, its applications are restricted by lower mechanical potency, low colloidal stability, and uncontrolled drug release. The composition of HA with polymers removes its defects as a drug delivery system. Hence, this paper provides clear information on the latest Hydroxyapatite nanocomposites (HAP-PNs) improvements as drug delivery systems. So, it supplies a precise insight into the various synthesis methods of HAp-PNs and newly developed nanocarriers from HAp-PNs. Moreover, this review confers HAp-PNs nanocarrier's possible usage and restrictions in different fields of medicine.</div></div>","PeriodicalId":12015,"journal":{"name":"European Journal of Medicinal Chemistry Reports","volume":"12 ","pages":"Article 100231"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Medicinal Chemistry Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772417424001031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Prescribing drugs in a traditional way causes drug resistance and side effects. New strategies are being developed to solve these problems and to deliver drugs safely and efficiently to damaged tissues. Drug delivery systems are one of the successful strategies for delivering drugs to the disease site in the body. Hydroxyapatite (HA) due to its similarity to the compositional of bone and tooth and biocompatibility has received more attention in biomedical applications. Nonetheless, its applications are restricted by lower mechanical potency, low colloidal stability, and uncontrolled drug release. The composition of HA with polymers removes its defects as a drug delivery system. Hence, this paper provides clear information on the latest Hydroxyapatite nanocomposites (HAP-PNs) improvements as drug delivery systems. So, it supplies a precise insight into the various synthesis methods of HAp-PNs and newly developed nanocarriers from HAp-PNs. Moreover, this review confers HAp-PNs nanocarrier's possible usage and restrictions in different fields of medicine.

查看原文本刊更多论文

用于给药应用的羟基磷灰石-聚合物纳米复合材料：微型综述

传统的用药方式会产生抗药性和副作用。目前正在开发新的策略来解决这些问题，并将药物安全有效地输送到受损组织。药物输送系统是将药物输送到体内疾病部位的成功策略之一。羟基磷灰石（HA）因其与骨骼和牙齿的成分相似且具有生物相容性，在生物医学应用中受到越来越多的关注。然而，由于其机械效力较低、胶体稳定性较差以及药物释放不受控制，其应用受到了限制。医管局与聚合物的组合消除了其作为给药系统的缺陷。因此，本文提供了有关羟基磷灰石纳米复合材料（HAP-PNs）作为给药系统的最新改进的明确信息。因此，本文对 HAp-PNs 的各种合成方法和新开发的 HAp-PNs 纳米载体提供了准确的见解。此外，这篇综述还介绍了 HAp-PNs 纳米载体在不同医学领域可能的用途和限制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Journal of Medicinal Chemistry Reports

CiteScore

4.50

自引率

0.00%

发文量