Aspergillus fumigatus sensu stricto genetic diversity from cystic fibrosis patients

IF 4.5 3区医学 Q1 MICROBIOLOGY

International Journal of Medical Microbiology Pub Date : 2024-10-22 DOI:10.1016/j.ijmm.2024.151639

Aryse Martins Melo , Vanice Rodrigues Poester , Mariana Rodrigues Trápaga , Fernando Azevedo Faria , Valério Aquino , Cecília Bittencourt Severo , David A. Stevens , Cristina Veríssimo , Raquel Sabino , Melissa Orzechowski Xavier

引用次数: 0

Abstract

We aimed to access the genetic diversity of Apergillus fumigatus strains obtained from cystic fibrosis (CF) patients from southern Brazil. A. fumigatus sensu stricto isolates from respiratory clinical specimens were genotyped by microsatellite markers and azole resistance was evaluated by azole-agar screening. Twenty-seven isolates from twenty-seven patients showed a high genetic diversity, with the differentiation of 25 different genotypes (25 unique and one common to two isolates). All isolates were susceptible to the azoles tested. We believe that prospectively monitoring A. fumigatus genetic diversity is essential to identify interpatient transmission and outbreaks, as is the identification of resistant strains.

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来自囊性纤维化患者的严格意义上的烟曲霉遗传多样性

我们的目的是了解从巴西南部囊性纤维化（CF）患者体内获得的烟曲霉菌株的遗传多样性。通过微卫星标记对呼吸道临床标本中的严格意义上的烟曲霉分离株进行了基因分型，并通过唑-琼脂筛选评估了唑抗性。来自 27 名患者的 27 个分离株显示出高度的遗传多样性，分化出 25 种不同的基因型（25 种独特的基因型和一种两个分离株共有的基因型）。所有分离株都对测试的唑类药物敏感。我们认为，前瞻性地监测烟曲霉的遗传多样性对于识别患者间传播和疫情爆发以及耐药菌株的鉴定至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Medical Microbiology 医学-病毒学

CiteScore

9.70

自引率

0.00%

发文量

审稿时长

45 days

期刊介绍： Pathogen genome sequencing projects have provided a wealth of data that need to be set in context to pathogenicity and the outcome of infections. In addition, the interplay between a pathogen and its host cell has become increasingly important to understand and interfere with diseases caused by microbial pathogens. IJMM meets these needs by focussing on genome and proteome analyses, studies dealing with the molecular mechanisms of pathogenicity and the evolution of pathogenic agents, the interactions between pathogens and host cells ("cellular microbiology"), and molecular epidemiology. To help the reader keeping up with the rapidly evolving new findings in the field of medical microbiology, IJMM publishes original articles, case studies and topical, state-of-the-art mini-reviews in a well balanced fashion. All articles are strictly peer-reviewed. Important topics are reinforced by 2 special issues per year dedicated to a particular theme. Finally, at irregular intervals, current opinions on recent or future developments in medical microbiology are presented in an editorial section.