Inhibitors of metal catalyzed lipid peroxidation reactions inhibit mucus secretion and 15 hete levels in canine trachea

Herbert G. Johnson, Martha L. McNee, J. Mark Braughler
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引用次数: 2

Abstract

Inhibition of canine mucus secretion in vivo induced by arachidonic acid administration was correlated with a reduction of 15 Hete levels in canine mucus. Antioxidants and inhibitors of lipid peroxidation were effective inhibitors of both mucus secretion and 15 Hete production. This same series of inhibitors also dose dependently inhibited Fe2+ dependent oxidation of arachidonic acid in vitro as assessed by an inhibition of thiobarbituric acid reactive material and conjugated diene formation. These data argue for an involvement of reactive oxygen species and lipid peroxidation in the generation and elaboration of mucus secretion.

金属催化的脂质过氧化反应抑制剂抑制犬气管粘液分泌和15 hete水平
花生四烯酸在体内诱导的犬黏液分泌抑制与犬黏液中15 Hete水平的降低相关。抗氧化剂和脂质过氧化抑制剂是粘液分泌和15 - Hete生成的有效抑制剂。通过抑制硫代巴比妥酸反应物质和共轭二烯的形成,这一系列抑制剂也在体外剂量依赖性地抑制了花生四烯酸的Fe2+依赖性氧化。这些数据表明活性氧和脂质过氧化作用参与了粘液分泌的产生和细化。
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