MSOR6 Presentation Time: 5:25 PM

IF 1.7 4区医学 Q4 ONCOLOGY

Brachytherapy Pub Date : 2024-10-25 DOI:10.1016/j.brachy.2024.08.040

Gustavo R. Sarria MD, Cas Dejonckheere MD, Julian Layer MD, Katharina Layer MD, Andrea Glasmacher MD, Davide Scafa MD, Eleni Gkika MD

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引用次数: 0

Abstract

Purpose

Intraoperative radiotherapy (IORT) has become a viable treatment option for resectable brain metastases (BMs). As data on local control and radiation necrosis rates are maturing, we focus on meaningful secondary endpoints such as time to next treatment (TTNT), duration of postoperative corticosteroid treatment, and in-hospital time.

Methods

Patients prospectively recruited within an IORT study registry between November 2020 and June 2023 were compared with consecutive patients receiving adjuvant stereotactic radiotherapy (SRT) of the resection cavity within the same time frame. TTNT was defined as the number of days between BM resection and start of the next extracranial oncological therapy (systemic treatment, surgery, or radiotherapy) for each of the groups.

Results

Of 95 BM patients screened, IORT was feasible in 84 cases (88%) and ultimately performed in 64 (67%). The control collective consisted of 53 SRT patients. There were no relevant differences in clinical baseline features. Mean TTNT (range) was 36 (9 − 94) days for IORT patients versus 52 (11 − 126) days for SRT patients (p = 0.01). Mean duration of postoperative corticosteroid treatment was similar (8 days; p = 0.83), as was mean postoperative in-hospital time (11 versus 12 days; p = 0.97). Mean total in-hospital time for BM treatment (in- and out-patient days) was 11 days for IORT versus 19 days for SRT patients (p 0.001).

Conclusion

IORT for BMs results in faster completion of interdisciplinary treatment when compared to adjuvant SRT, without increasing corticosteroid intake or prolonging in-hospital times. A randomised phase III trial will determine the clinical effects of shorter TTNT.

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MSOR6 演讲时间：下午 5:25

目的术中放疗（IORT）已成为可切除脑转移瘤（BMs）的可行治疗方案。方法将 2020 年 11 月至 2023 年 6 月期间在 IORT 研究登记处前瞻性招募的患者与在同一时间内接受切除腔辅助立体定向放射治疗 (SRT) 的连续患者进行比较。TTNT定义为每组患者从接受骨髓瘤切除术到开始下一次颅外肿瘤治疗（全身治疗、手术或放疗）之间的天数。结果在筛选出的95例骨髓瘤患者中，84例（88%）可行IORT，64例（67%）最终实施了IORT。对照组由 53 名 SRT 患者组成。临床基线特征无相关差异。IORT 患者的平均 TTNT（范围）为 36（9 - 94）天，而 SRT 患者为 52（11 - 126）天（p = 0.01）。术后皮质类固醇治疗的平均持续时间相似（8 天；p = 0.83），术后平均住院时间也相似（11 天对 12 天；p = 0.97）。结论IORT治疗BM与SRT辅助治疗相比，能更快地完成跨学科治疗，同时不会增加皮质类固醇的摄入量或延长住院时间。随机III期试验将确定缩短TTNT的临床效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brachytherapy 医学-核医学

CiteScore

3.40

自引率

21.10%

发文量

119

审稿时长

9.1 weeks

期刊介绍： Brachytherapy is an international and multidisciplinary journal that publishes original peer-reviewed articles and selected reviews on the techniques and clinical applications of interstitial and intracavitary radiation in the management of cancers. Laboratory and experimental research relevant to clinical practice is also included. Related disciplines include medical physics, medical oncology, and radiation oncology and radiology. Brachytherapy publishes technical advances, original articles, reviews, and point/counterpoint on controversial issues. Original articles that address any aspect of brachytherapy are invited. Letters to the Editor-in-Chief are encouraged.