Analysis of Specific IgE Distribution Characteristics of Dust Mite Allergen Components in Patients With Atopic Dermatitis

IF 3.7 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2024-10-26 DOI:10.1155/2024/8961289

Zixing Cui, Ling Fang, Min Sun, Juan Liu, Hua Guo

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Abstract

Objective: To investigate the distribution characteristics of specific immunoglobulin E (IgE) to dust mite components in patients with atopic dermatitis (AD), aiming to provide a reference basis for the development of microarray protein chips for allergen component discrimination diagnosis and personalized desensitization therapy.

Methods: A total of 55 patients who visited Huishan District People’s Hospital of Wuxi City, Xishan People’s Hospital of Wuxi City, and People’s Hospital of Wuxi City from January 2023 to December 2023 were selected. The results of serum total IgE (total IgE) and specific IgE detection were analyzed.

Results: Among the 55 patients, 54 (98.2%) were positive (cutoff value > 0.35 Ua/mL, the normal value for serum total IgE is under 150–400 IU/mL) for serum total IgE antibodies, 52 (94.6%) were positive for Dermatophagoides pteronyssinus (Dp)–specific IgE antibodies, and 50 (90.9%) were positive for Dermatophagoides farinae (Df)–specific IgE antibodies. The protein chip results were consistent with the existing Phadia detection results.

Conclusion: The development of chips based on CRD (component-resolved diagnosis) cannot only rely on IgE binding rate to assist in precise treatment of patients but also choose personalized desensitization therapy, providing more practical recommendations for preventing cross-allergy, avoiding allergic environments, or ingesting sensitizing foods for susceptible individuals.

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特应性皮炎患者尘螨过敏原成分的特异性 IgE 分布特点分析

目的研究特应性皮炎（AD）患者体内针对尘螨成分的特异性免疫球蛋白E（IgE）的分布特征，旨在为过敏原成分鉴别诊断和个性化脱敏治疗的微阵列蛋白芯片开发提供参考依据。研究方法选取2023年1月至2023年12月在无锡市惠山区人民医院、无锡市锡山区人民医院、无锡市人民医院就诊的55例患者为研究对象。分析血清总IgE（总IgE）和特异性IgE的检测结果。结果55例患者中，54例（98.2%）血清总IgE抗体阳性（临界值> 0.35 Ua/mL，血清总IgE的正常值为150-400 IU/mL以下），52例（94.6%）Dermatophagoides pteronyssinus（Dp）特异性IgE抗体阳性，50例（90.9%）Dermatophagoides farinae（Df）特异性IgE抗体阳性。蛋白芯片结果与现有的 Phadia 检测结果一致。结论基于CRD（成分分辨诊断）的芯片开发不仅可以依靠IgE结合率辅助对患者进行精确治疗，还可以选择个性化的脱敏疗法，为易感人群预防交叉过敏、避免过敏环境或摄入致敏食物提供更实用的建议。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.