LaMer-model-based synthesis method for fine particles of octacalcium phosphate and related functional compounds†

IF 2.6 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
CrystEngComm Pub Date : 2024-09-25 DOI:10.1039/D4CE00663A
Taishi Yokoi, Tomoyo Goto, Tohru Sekino, Tomoka Hasegawa, Peng Chen, Hiroyasu Kanetaka, Kaname Yoshida, Masaya Shimabukuro and Masakazu Kawashita
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Abstract

Octacalcium phosphate (OCP) is a fascinating calcium phosphate material with a layered structure that can incorporate various guest molecules, particularly dicarboxylate ions. However, the solution-phase synthesis of OCP fine particles is challenging. In this study, we developed a new precipitation method based on the LaMer model for synthesising fine particles of plain OCP and OCP with incorporated isophthalate and succinate ions. Highly concentrated aqueous solutions and appropriate reaction conditions yielded particle sizes of 100–200 nm for plain OCP and 200–300 nm for OCP with incorporated dicarboxylate ions. The obtained particle sizes were significantly smaller than those of OCPs synthesised using conventional methods. The incorporation of isophthalate and succinate ions into OCP was confirmed using various methods, particularly X-ray diffraction, which revealed expansion of the (100) interplanar spacing. During the synthesis of OCP with incorporated isophthalate ions, hydrolysis of the OCP phase was minimised when the initial pH range of the isophthalic acid solution was 5.2–5.3. Interestingly, OCP with incorporated isophthalate ions exhibited fluorescence (excitation and emission at 325 and 390 nm, respectively), demonstrating the potential of these fine particles as novel biofriendly fluorescent probes. This novel LaMer-model-based synthesis for preparing fine particles of OCP and OCP with incorporated functional carboxylate ions can contribute to the design and development of next-generation biofriendly imaging probes and other functional calcium phosphate materials, such as for use in biosensing and drug delivery applications.

Abstract Image

基于 LaMer 模型的磷酸八钙及相关功能化合物细颗粒合成方法†.
磷酸八钙(OCP)是一种迷人的磷酸钙材料,它具有层状结构,可以吸附各种客体分子,尤其是二羧酸根离子。然而,溶液相合成 OCP 微粒具有挑战性。在本研究中,我们开发了一种基于 LaMer 模型的新沉淀法,用于合成普通 OCP 和含有间苯二甲酸根离子和琥珀酸根离子的 OCP 微粒。在高浓度水溶液和适当的反应条件下,普通 OCP 的粒径为 100-200 nm,含有二羧酸根离子的 OCP 的粒径为 200-300 nm。所获得的粒径明显小于用传统方法合成的 OCP。使用各种方法,特别是 X 射线衍射法,证实了 OCP 中掺入了间苯二甲酸盐和琥珀酸盐离子,X 射线衍射法显示 (100) 平面间距有所扩大。在合成含有间苯二甲酸根离子的 OCP 的过程中,当间苯二甲酸溶液的初始 pH 值范围为 5.2-5.3 时,OCP 相的水解作用最小。有趣的是,掺入了间苯二甲酸根离子的 OCP 显示出荧光(激发和发射波长分别为 325 纳米和 390 纳米),这表明这些微粒具有作为新型生物友好型荧光探针的潜力。这种基于 LaMer 模型的新型合成方法可制备 OCP 和含有功能性羧酸根离子的 OCP 微粒,有助于设计和开发下一代生物友好型成像探针和其他功能性磷酸钙材料,例如用于生物传感和药物递送应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CrystEngComm
CrystEngComm 化学-化学综合
CiteScore
5.50
自引率
9.70%
发文量
747
审稿时长
1.7 months
期刊介绍: Design and understanding of solid-state and crystalline materials
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