Balancing acts: The posttranslational modification tightrope of flavivirus replication.

IF 5.5 1区医学 Q1 MICROBIOLOGY

PLoS Pathogens Pub Date : 2024-10-28 eCollection Date: 2024-10-01 DOI:10.1371/journal.ppat.1012626

RuthMabel Boytz, Maudry Laurent-Rolle

引用次数: 0

Abstract

Posttranslational modifications (PTMs) such as phosphorylation, ubiquitination, SUMOylation, and ISGylation are involved in various cellular pathways, including innate immunity and disease processes. Many viruses have developed sophisticated mechanisms to modulate these host PTMs, either by inhibiting the interferon pathway or by enhancing the stability and function of viral proteins essential for replication. In this Pearl, we review the literature on how flaviviruses are impacted by and exploit posttranslational modifications to their advantage.

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平衡行为：黄病毒复制的翻译后修饰紧箍咒。

磷酸化、泛素化、SUMOylation 和 ISGylation 等翻译后修饰（PTM）参与了各种细胞通路，包括先天免疫和疾病过程。许多病毒都开发出了复杂的机制来调节宿主的这些 PTMs，或是通过抑制干扰素途径，或是通过增强复制所必需的病毒蛋白的稳定性和功能。在这篇论文中，我们回顾了有关黄病毒如何受到翻译后修饰的影响并利用翻译后修饰发挥自身优势的文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PLoS Pathogens MICROBIOLOGY-PARASITOLOGY

自引率

3.00%

发文量

598

期刊介绍： Bacteria, fungi, parasites, prions and viruses cause a plethora of diseases that have important medical, agricultural, and economic consequences. Moreover, the study of microbes continues to provide novel insights into such fundamental processes as the molecular basis of cellular and organismal function.