The neutropenic diet and its impacts on clinical, nutritional, and lifestyle outcomes for people with cancer: a scoping review.

IF 2.4 Q3 NUTRITION & DIETETICS
Journal of Nutritional Science Pub Date : 2024-10-10 eCollection Date: 2024-01-01 DOI:10.1017/jns.2024.61
Trinity Gulliver, Melissa Hewett, Panagiotis Konstantopoulos, Lisa Tran, Evangeline Mantzioris
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引用次数: 0

Abstract

The neutropenic diet (ND) is often recommended to people with cancer to reduce infection risk despite recommendations of clinical guidelines advising against its use. While recent literature suggests the ND does not reduce infection risk, other outcomes related to health, nutrition, and lifestyle are unknown. The aim of this review is to systematically scope the literature on the ND in people with cancer for all outcomes related to clinical health, nutrition, and lifestyle. Scientific databases were systematically searched. Eligible studies were in English, people with any cancer type, consuming an ND, any age group, date, or setting. Eligible study types were randomised control trials, observational studies, systematic reviews, and meta-analyses. Twenty-one studies met the inclusion criteria. Outcomes of interest found were infection rates, fever, mortality, antibiotic use, gastrointestinal side effects, comorbidities, biochemistry, hospitalisation, nutritional status, quality of life (QoL), well-being, and financial costs. Most research has focused on infection and mortality rates with few assessing hospitalisation rates, nutritional status, financial costs, and QoL. Most included studies found no significant differences between ND and comparator diet for mortality, antibiotics use, comorbidities, and QoL; however, several studies reported the ND significantly increased the risk of infection. Gaps in the literature included effect of ND on QoL in an adult population, microbiome, lifestyle changes, and financial burden. Further research is needed regarding how the ND affects the microbiome and QoL of its consumers, but in the interim, it is important for hospitals providing an ND to their patients to liberalise the ND wherever possible.

中性粒细胞饮食及其对癌症患者临床、营养和生活方式结果的影响:范围界定综述。
尽管临床指南建议不要使用中性粒细胞饮食(ND),但为了降低感染风险,人们还是经常向癌症患者推荐这种饮食。虽然最近的文献表明 ND 不会降低感染风险,但与健康、营养和生活方式相关的其他结果尚不清楚。本综述旨在系统地研究有关癌症患者使用 ND 的文献,以了解与临床健康、营养和生活方式相关的所有结果。我们系统地搜索了科学数据库。符合条件的研究为英文研究,研究对象为任何癌症类型、食用 ND、任何年龄段、任何日期或任何环境的癌症患者。符合条件的研究类型包括随机对照试验、观察性研究、系统综述和荟萃分析。21 项研究符合纳入标准。所发现的相关结果包括感染率、发热、死亡率、抗生素使用、胃肠道副作用、合并症、生化、住院、营养状况、生活质量(QoL)、幸福感和经济成本。大多数研究侧重于感染率和死亡率,很少有研究对住院率、营养状况、经济成本和 QoL 进行评估。大多数纳入的研究发现,在死亡率、抗生素使用、并发症和 QoL 方面,玖龙纸业与对比饮食之间没有明显差异;但有几项研究报告称,玖龙纸业会显著增加感染风险。文献中的空白包括 ND 对成年人群 QoL 的影响、微生物组、生活方式的改变以及经济负担。关于玖龙牌如何影响其消费者的微生物组和 QoL,还需要进一步研究,但在此期间,为患者提供玖龙牌的医院必须尽可能放开玖龙牌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Nutritional Science
Journal of Nutritional Science NUTRITION & DIETETICS-
CiteScore
3.00
自引率
0.00%
发文量
91
审稿时长
7 weeks
期刊介绍: Journal of Nutritional Science is an international, peer-reviewed, online only, open access journal that welcomes high-quality research articles in all aspects of nutrition. The underlying aim of all work should be, as far as possible, to develop nutritional concepts. JNS encompasses the full spectrum of nutritional science including public health nutrition, epidemiology, dietary surveys, nutritional requirements, metabolic studies, body composition, energetics, appetite, obesity, ageing, endocrinology, immunology, neuroscience, microbiology, genetics, molecular and cellular biology and nutrigenomics. JNS welcomes Primary Research Papers, Brief Reports, Review Articles, Systematic Reviews, Workshop Reports, Letters to the Editor and Obituaries.
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