The mechanisms behind heatstroke-induced intestinal damage.

IF 6.1 2区 生物学 Q1 CELL BIOLOGY
Minshu Sun, Qin Li, Zhimin Zou, Jian Liu, Zhengtao Gu, Li Li
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Abstract

With the frequent occurrence of heatwaves, heatstroke (HS) is expected to become one of the main causes of global death. Being a multi-organized disease, HS can result in circulatory disturbance and systemic inflammatory response, with the gastrointestinal tract being one of the primary organs affected. Intestinal damage plays an initiating and promoting role in HS. Multiple pathways result in damage to the integrity of the intestinal epithelial barrier due to heat stress and hypoxia brought on by blood distribution. This usually leads to intestinal leakage as well as the infiltration and metastasis of toxins and pathogenic bacteria in the intestinal cavity, which will eventually cause inflammation in the whole body. A large number of studies have shown that intestinal damage after HS involves the body's stress response, disruption of oxidative balance, disorder of tight junction proteins, massive cell death, and microbial imbalance. Based on these damage mechanisms, protecting the intestinal barrier and regulating the body's inflammatory and immune responses are effective treatment strategies. To better understand the pathophysiology of this complex process, this review aims to outline the potential processes and possible therapeutic strategies for intestinal damage after HS in recent years.

中暑诱发肠道损伤的机制。
随着热浪的频繁出现,中暑(HS)预计将成为全球死亡的主要原因之一。作为一种多器官疾病,中暑可导致循环障碍和全身炎症反应,而胃肠道是主要受累器官之一。肠道损伤在 HS 中起着启动和促进作用。由于热应激和血液分布造成的缺氧,多种途径导致肠道上皮屏障完整性受损。这通常会导致肠道渗漏以及毒素和致病菌在肠腔内的浸润和转移,最终引起全身炎症。大量研究表明,HS 后的肠道损伤涉及机体的应激反应、氧化平衡破坏、紧密连接蛋白紊乱、大量细胞死亡和微生物失衡。基于这些损伤机制,保护肠道屏障、调节机体炎症和免疫反应是有效的治疗策略。为了更好地理解这一复杂过程的病理生理学,本综述旨在概述近年来 HS 后肠道损伤的潜在过程和可能的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell Death Discovery
Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
8.30
自引率
1.40%
发文量
468
审稿时长
9 weeks
期刊介绍: Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.
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