Autophagy: a critical mechanism of N6-methyladenosine modification involved in tumor progression and therapy resistance.

IF 8.1 1区 生物学 Q1 CELL BIOLOGY
Feiyang Wang, Qiudi Liao, Zihao Qin, Jingyi Li, Qingqing Wei, Mengna Li, Hongyu Deng, Wei Xiong, Ming Tan, Ming Zhou
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引用次数: 0

Abstract

N6-Methyladenosine (m6A) is an evolutionarily highly conserved epigenetic modification that affects eukaryotic RNAs, especially mRNAs, and m6A modification is commonly linked to tumor proliferation, progression, and therapeutic resistance by participating in RNA metabolism. Autophagy is an intracellular degradation and recycling biological process by which cells remove damaged organelles, protein aggregates, and other intracellular wastes, and release nutrients to maintain cell survival when energy is scarce. Recent studies have shown that m6A modification plays a critical role in the regulation of autophagy, affecting the initiation of autophagy, the formation and assembly of autophagosomes, and lysosomal function by regulating critical regulatory molecules involved in the process of autophagy. Moreover, autophagy can also affect the expression of the three types of regulators related to m6A, which in turn affects the levels of their target genes via m6A modification. Thus, m6A modification and autophagy form a sophisticated regulatory network through mutual regulation, which plays an important role in tumor progression and therapeutic resistance. In this manuscript, we reviewed the effects of m6A modification on autophagy as well as the effects of autophagy on m6A modification and the roles of the m6A-autophagy axis in tumor progression and therapy resistance. Additionally, we summarized the value and application prospects of key molecules in the m6A-autophagy axis in tumor diagnosis and therapy.

自噬:N6-甲基腺苷修饰参与肿瘤进展和耐药性的关键机制。
N6-甲基腺苷(m6A)是一种在进化过程中高度保守的表观遗传修饰,它会影响真核生物的 RNA,尤其是 mRNA,m6A 修饰通过参与 RNA 代谢,通常与肿瘤的增殖、进展和耐药性有关。自噬是一种细胞内降解和回收的生物过程,细胞通过自噬清除受损细胞器、蛋白质聚集体和其他细胞内废物,并在能量缺乏时释放营养物质以维持细胞存活。最近的研究表明,m6A修饰在自噬的调控中起着关键作用,它通过调节参与自噬过程的关键调控分子,影响自噬的启动、自噬小体的形成和组装以及溶酶体功能。此外,自噬还能影响与 m6A 相关的三类调控因子的表达,进而通过 m6A 修饰影响其靶基因的水平。因此,m6A修饰和自噬通过相互调控形成了一个复杂的调控网络,在肿瘤进展和治疗耐药中发挥着重要作用。在这篇手稿中,我们综述了 m6A 修饰对自噬的影响、自噬对 m6A 修饰的影响以及 m6A- 自噬轴在肿瘤进展和耐药性中的作用。此外,我们还总结了m6A-自噬轴中关键分子在肿瘤诊断和治疗中的价值和应用前景。
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来源期刊
Cell Death & Disease
Cell Death & Disease CELL BIOLOGY-
CiteScore
15.10
自引率
2.20%
发文量
935
审稿时长
2 months
期刊介绍: Brought to readers by the editorial team of Cell Death & Differentiation, Cell Death & Disease is an online peer-reviewed journal specializing in translational cell death research. It covers a wide range of topics in experimental and internal medicine, including cancer, immunity, neuroscience, and now cancer metabolism. Cell Death & Disease seeks to encompass the breadth of translational implications of cell death, and topics of particular concentration will include, but are not limited to, the following: Experimental medicine Cancer Immunity Internal medicine Neuroscience Cancer metabolism
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